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Systemic Immune Activation Profiles of HIV-1 Subtype C-Infected Children and Their Mothers
Joint Authors
Anderson, Ronald
Theron, A. J.
Makhubele, Tinyiko G.
van Dyk, Gisela
Rossouw, Theresa M.
Steel, Helen C.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Little is known about immune activation profiles of children infected with HIV-1 subtype C.
The current study compared levels of selected circulating biomarkers of immune activation in HIV-1 subtype C-infected untreated mothers and their children with those of healthy controls.
Multiplex bead array, ELISA, and immunonephelometric procedures were used to measure soluble CD14 (sCD14), beta-2 microglobulin (β2M), CRP, MIG, IP-10, and transforming growth factor beta 1 (TGF-β1).
Levels of all 6 biomarkers were significantly elevated in the HIV-infected mothers and, with the exception of MIG, in their children ( P < 0.01 – P < 0.0001 ).
The effects of antiretroviral therapy (ART) and maternal smoking on these biomarkers were also assessed.
With the exception of TGF-β1, which was unchanged in the children 12 months after therapy, initiation of ART was accompanied by decreases in the other biomarkers.
Regression analysis revealed that although most biomarkers were apparently unaffected by smoking, exposure of children to maternal smoking was associated with a significant increase in IP-10.
These findings demonstrate that biomarkers of immune activation are elevated in HIV-infected children pre-ART and decline, with the exception of TGF-β1, after therapy.
Although preliminary, elevation of IP-10 in smoke-exposed infants is consistent with a higher level of immune activation in this group.
American Psychological Association (APA)
Makhubele, Tinyiko G.& Steel, Helen C.& Anderson, Ronald& van Dyk, Gisela& Theron, A. J.& Rossouw, Theresa M.. 2016. Systemic Immune Activation Profiles of HIV-1 Subtype C-Infected Children and Their Mothers. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1111280
Modern Language Association (MLA)
Makhubele, Tinyiko G.…[et al.]. Systemic Immune Activation Profiles of HIV-1 Subtype C-Infected Children and Their Mothers. Mediators of Inflammation No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1111280
American Medical Association (AMA)
Makhubele, Tinyiko G.& Steel, Helen C.& Anderson, Ronald& van Dyk, Gisela& Theron, A. J.& Rossouw, Theresa M.. Systemic Immune Activation Profiles of HIV-1 Subtype C-Infected Children and Their Mothers. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1111280
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111280