SP600125 Attenuates Nicotine-Related Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase Production and CC Chemokine-Mediated Macrophage Migration
Joint Authors
Li, Zong-Zhuang
Guo, Zhen-Zhen
Cao, Qun-An
Liu, Li-Ping
Zhang, Zhi
Zhu, Ya-Juan
Chu, Guang
Dai, Qiu-Yan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Nicotine, a major chemical component of cigarettes, plays a pivotal role in the development of abdominal aortic aneurysm (AAA).
c-Jun N-terminal kinase (JNK) has been demonstrated to participate in elastase-induced AAA.
This study aimed to elucidate whether the JNK inhibitor SP600125 can attenuate nicotine plus angiotensin II- (AngII-) induced AAA formation and to assess the underlying molecular mechanisms.
SP600125 significantly attenuated nicotine plus AngII-induced AAA formation.
The expression of matrix metalloproteinase- (MMP-) 2, MMP-9, monocyte chemoattractant protein- (MCP-) 1, and regulated-on-activation, normal T-cells expressed and secreted (RANTES) was significantly upregulated in aortic aneurysm lesions but inhibited by SP600125.
In vitro, nicotine induced the expression of MCP-1 and RANTES in both RAW264.7 (mouse macrophage) and MOVAS (mouse vascular smooth muscle) cells in a dose-dependent manner; expression was upregulated by 0.5 ng/mL nicotine but strongly downregulated by 500 ng/mL nicotine.
SP600125 attenuated the upregulation of MCP-1 and RANTES expression and subsequent macrophage migration.
In conclusion, SP600125 attenuates nicotine plus AngII-induced AAA formation likely by inhibiting MMP-2, MMP-9, MCP-1, and RANTES.
The expression of chemokines in MOVAS cells induced by nicotine has an effect on RAW264.7 migration, which is likely to contribute to the development of nicotine-related AAA.
American Psychological Association (APA)
Guo, Zhen-Zhen& Cao, Qun-An& Li, Zong-Zhuang& Liu, Li-Ping& Zhang, Zhi& Zhu, Ya-Juan…[et al.]. 2016. SP600125 Attenuates Nicotine-Related Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase Production and CC Chemokine-Mediated Macrophage Migration. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111284
Modern Language Association (MLA)
Guo, Zhen-Zhen…[et al.]. SP600125 Attenuates Nicotine-Related Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase Production and CC Chemokine-Mediated Macrophage Migration. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111284
American Medical Association (AMA)
Guo, Zhen-Zhen& Cao, Qun-An& Li, Zong-Zhuang& Liu, Li-Ping& Zhang, Zhi& Zhu, Ya-Juan…[et al.]. SP600125 Attenuates Nicotine-Related Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase Production and CC Chemokine-Mediated Macrophage Migration. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111284
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111284