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Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis
Joint Authors
Bertolotto, Maria
Pende, Aldo
Dallegri, Franco
Lenglet, Sébastien
Montecucco, Fabrizio
Carbone, Federico
Palombo, Domenico
Cea, Michele
Bonaventura, Aldo
Roth, Aline
Burger, Fabienne
Brandt, Karim J.
Spinella, Giovanni
Pane, Bianca
Mach, François
Vuilleumier, N.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Serum c-reactive protein (CRP) was suggested for the assessment of intermediate cardiovascular (CV) risk.
Here, systemic or intraplaque CRP levels were investigated as predictors of major adverse cardiovascular events (MACEs) in patients with severe carotid stenosis.
CRP levels were assessed in the serum and within different portions (upstream and downstream) of carotid plaques of 217 patients undergoing endarterectomy.
The association between CRP and intraplaque lipids, collagen, neutrophils, smooth muscle cells (SMC), and macrophage subsets was determined.
No correlation between serum CRP and intraplaque biomarkers was observed.
In upstream portions, CRP content was directly correlated with intraplaque neutrophils, total macrophages, and M1 macrophages and inversely correlated with SMC content.
In downstream portions, intraplaque CRP correlated with M1 and M2 macrophages.
According to the cut-off point (CRP > 2.9%) identified by ROC analysis in upstream portions, Kaplan-Meier analysis showed that patients with high CRP levels had a greater rate of MACEs.
This risk of MACEs increased independently of age, male gender, serum CRP, and statin use.
In conclusion, in patients with severe carotid artery stenosis, high CRP levels within upstream portions of carotid plaques directly and positively correlate with intraplaque inflammatory cells and predict MACEs at an 18-month follow-up period.
American Psychological Association (APA)
Bonaventura, Aldo& Mach, François& Roth, Aline& Lenglet, Sébastien& Burger, Fabienne& Brandt, Karim J.…[et al.]. 2016. Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111285
Modern Language Association (MLA)
Bonaventura, Aldo…[et al.]. Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1111285
American Medical Association (AMA)
Bonaventura, Aldo& Mach, François& Roth, Aline& Lenglet, Sébastien& Burger, Fabienne& Brandt, Karim J.…[et al.]. Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111285
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111285