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Bigelovii A Protects against Lipopolysaccharide-Induced Acute Lung Injury by Blocking NF-κB and CCAATEnhancer-Binding Protein δ Pathways
Joint Authors
Tang, Hui-Fang
Yan, Chunguang
Guan, Fuqin
Shen, Yanfei
Yuan, Dong
Gao, Hongwei
Feng, Xu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Optimal methods are applied to acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS), but the mortality rate is still high.
Accordingly, further studies dedicated to identify novel therapeutic approaches to ALI are urgently needed.
Bigelovii A is a new natural product and may exhibit anti-inflammatory activity.
Therefore, we sought to investigate its effect on lipopolysaccharide- (LPS-) induced ALI and the underlying mechanisms.
We found that LPS-induced ALI was significantly alleviated by Bigelovii A treatment, characterized by reduction of proinflammatory mediator production, neutrophil infiltration, and lung permeability.
Furthermore, Bigelovii A also downregulated LPS-stimulated inflammatory mediator expressions in vitro.
Moreover, both NF-κB and CCAAT/enhancer-binding protein δ (C/EBPδ) activation were obviously attenuated by Bigelovii A treatment.
Additionally, phosphorylation of both p38 MAPK and ERK1/2 (upstream signals of C/EBPδ activation) in response to LPS challenge was also inhibited by Bigelovii A.
Therefore, Bigelovii A could attenuate LPS-induced inflammation by suppression of NF-κB, inflammatory mediators, and p38 MAPK/ERK1/2—C/EBPδ, inflammatory mediators signaling pathways, which provide a novel theoretical basis for the possible application of Bigelovii A in clinic.
American Psychological Association (APA)
Yan, Chunguang& Guan, Fuqin& Shen, Yanfei& Tang, Hui-Fang& Yuan, Dong& Gao, Hongwei…[et al.]. 2016. Bigelovii A Protects against Lipopolysaccharide-Induced Acute Lung Injury by Blocking NF-κB and CCAATEnhancer-Binding Protein δ Pathways. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111289
Modern Language Association (MLA)
Yan, Chunguang…[et al.]. Bigelovii A Protects against Lipopolysaccharide-Induced Acute Lung Injury by Blocking NF-κB and CCAATEnhancer-Binding Protein δ Pathways. Mediators of Inflammation No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1111289
American Medical Association (AMA)
Yan, Chunguang& Guan, Fuqin& Shen, Yanfei& Tang, Hui-Fang& Yuan, Dong& Gao, Hongwei…[et al.]. Bigelovii A Protects against Lipopolysaccharide-Induced Acute Lung Injury by Blocking NF-κB and CCAATEnhancer-Binding Protein δ Pathways. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111289