Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis
Joint Authors
Ko, Seong-Gyu
Jang, Jong-Chan
Lee, Kang Min
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
We examined the protective effects of Angelica acutiloba Kitagawa (AAK) extract on a murine model of acute experimental colitis.
Colitis was induced by 4% dextran sulfate sodium (DSS) in the drinking water of male C57BL/6 mice, for 7 consecutive days.
Oral administration of AAK extract (500 mg/kg/day) significantly alleviated DSS-induced symptoms such as anorexia, weight loss, events of diarrhea or bloody stools, and colon shortening.
Histological damage was also ameliorated, as evidenced by the architectural preservation and suppression of inflammatory cell infiltration in colonic samples.
Treatment improved the colonic mRNA expression of different inflammatory markers: cytokines, inducible enzymes, matrix metalloproteinases, and tight junction-related proteins.
In the isolated serum, IgE levels were downregulated.
Collectively, these findings indicate the therapeutic potentials of AAK as an effective complementary or alternative modality for the treatment of ulcerative colitis.
American Psychological Association (APA)
Jang, Jong-Chan& Lee, Kang Min& Ko, Seong-Gyu. 2016. Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111291
Modern Language Association (MLA)
Jang, Jong-Chan…[et al.]. Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis. Mediators of Inflammation No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1111291
American Medical Association (AMA)
Jang, Jong-Chan& Lee, Kang Min& Ko, Seong-Gyu. Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111291
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111291