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Insights from lncRNAs Profiling of MIN6 Beta Cells Undergoing Inflammation
Joint Authors
Sun, Chuntao
Xue, Lihua
Zhu, Ziyang
Zhang, Fan
Yang, Ruixue
Yuan, Xuewen
Liu, Qianqi
Jia, Zhanjun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Type 1 diabetes mellitus (T1DM) is an organ-specific autoimmune disease characterized by chronic and progressive apoptotic destruction of pancreatic beta cells.
During the initial phases of T1DM, cytokines and other inflammatory mediators released by immune cells progressively infiltrate islet cells, induce alterations in gene expression, provoke functional impairment, and ultimately lead to apoptosis.
Long noncoding RNAs (lncRNAs) are a new important class of pervasive genes that have a variety of biological functions and play key roles in many diseases.
However, whether they have a function in cytokine-induced beta cell apoptosis is still uncertain.
In this study, lncRNA microarray technology was used to identify the differently expressed lncRNAs and mRNAs in MIN6 cells exposed to proinflammatory cytokines.
Four hundred forty-four upregulated and 279 downregulated lncRNAs were detected with a set filter fold-change ≧2.0.
To elucidate the potential functions of these lncRNAs, Gene Ontology (GO) and pathway analyses were used to evaluate the potential functions of differentially expressed lncRNAs.
Additionally, a lncRNA-mRNA coexpression network was constructed to predict the interactions between the most strikingly regulated lncRNAs and mRNAs.
This study may be utilized as a background or reference resource for future functional studies on lncRNAs related to the diagnosis and development of new therapies for T1DM.
American Psychological Association (APA)
Sun, Chuntao& Xue, Lihua& Zhu, Ziyang& Zhang, Fan& Yang, Ruixue& Yuan, Xuewen…[et al.]. 2016. Insights from lncRNAs Profiling of MIN6 Beta Cells Undergoing Inflammation. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111292
Modern Language Association (MLA)
Sun, Chuntao…[et al.]. Insights from lncRNAs Profiling of MIN6 Beta Cells Undergoing Inflammation. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1111292
American Medical Association (AMA)
Sun, Chuntao& Xue, Lihua& Zhu, Ziyang& Zhang, Fan& Yang, Ruixue& Yuan, Xuewen…[et al.]. Insights from lncRNAs Profiling of MIN6 Beta Cells Undergoing Inflammation. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111292