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Photobiomodulation Therapy Decreases Oxidative Stress in the Lung Tissue after Formaldehyde Exposure: Role of OxidantAntioxidant Enzymes
Joint Authors
Camara, Niels Olsen Saraiva
Marcourakis, Tania
Horliana, Anna Carolina Ratto Tempestini
Silva Macedo, Rodrigo
Peres Leal, Mayara
Braga, Tarcio Teodoro
Barioni, Éric Diego
de Oliveira Duro, Stephanie
Lino-dos-Santos-Franco, Adriana
Farsky, Sandra Helena Poliselli
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Formaldehyde is ubiquitous pollutant that induces oxidative stress in the lung.
Several lung diseases have been associated with oxidative stress and their control is necessary.
Photobiomodulation therapy (PBMT) has been highlighted as a promissory treatment, but its mechanisms need to be better investigated.
Our objective was to evaluate the effects of PBMT on the oxidative stress generated by FA exposure.
Male Wistar rats were submitted to FA exposure of 1% or vehicle (3 days) and treated or not with PBMT (1 and 5 h after each FA exposure).
Rats treated only with laser were used as control.
Twenty-four hours after the last FA exposure, we analyzed the effects of PBMT on the generation of nitrites and hydrogen peroxide, oxidative burst, glutathione reductase, peroxidase, S-transferase enzyme activities, the gene expression of nitric oxide, cyclooxygenase, superoxide dismutase, the catalase enzyme, and heme oxygenase-1.
PBMT reduced the generation of nitrites and hydrogen peroxide and increased oxidative burst in the lung cells.
A decreased level of oxidant enzymes was observed which were concomitantly related to an increased level of antioxidants.
This study provides new information about the antioxidant mechanisms of PBMT in the lung and might constitute an important tool for lung disease treatment.
American Psychological Association (APA)
Silva Macedo, Rodrigo& Peres Leal, Mayara& Braga, Tarcio Teodoro& Barioni, Éric Diego& de Oliveira Duro, Stephanie& Horliana, Anna Carolina Ratto Tempestini…[et al.]. 2016. Photobiomodulation Therapy Decreases Oxidative Stress in the Lung Tissue after Formaldehyde Exposure: Role of OxidantAntioxidant Enzymes. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1111294
Modern Language Association (MLA)
Silva Macedo, Rodrigo…[et al.]. Photobiomodulation Therapy Decreases Oxidative Stress in the Lung Tissue after Formaldehyde Exposure: Role of OxidantAntioxidant Enzymes. Mediators of Inflammation No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1111294
American Medical Association (AMA)
Silva Macedo, Rodrigo& Peres Leal, Mayara& Braga, Tarcio Teodoro& Barioni, Éric Diego& de Oliveira Duro, Stephanie& Horliana, Anna Carolina Ratto Tempestini…[et al.]. Photobiomodulation Therapy Decreases Oxidative Stress in the Lung Tissue after Formaldehyde Exposure: Role of OxidantAntioxidant Enzymes. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1111294
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111294