Epigenetic Modulation as a Therapeutic Prospect for Treatment of Autoimmune Rheumatic Diseases
Joint Authors
Ciechomska, Marzena
O’Reilly, Steven
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Systemic inflammatory rheumatic diseases are considered as autoimmune diseases, meaning that the balance between recognition of pathogens and avoidance of self-attack is impaired and the immune system attacks and destroys its own healthy tissue.
Treatment with conventional Disease Modifying Antirheumatic Drugs (DMARDs) and/or Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) is often associated with various adverse reactions due to unspecific and toxic properties of those drugs.
Although biologic drugs have largely improved the outcome in many patients, such drugs still pose significant problems and fail to provide a solution to all patients.
Therefore, development of more effective treatments and improvements in early diagnosis of rheumatic diseases are badly needed in order to increase patient’s functioning and quality of life.
The reversible nature of epigenetic mechanisms offers a new class of drugs that modulate the immune system and inflammation.
In fact, epigenetic drugs are already in use in some types of cancer or cardiovascular diseases.
Therefore, epigenetic-based therapeutics that control autoimmunity and chronic inflammatory process have broad implications for the pathogenesis, diagnosis, and management of rheumatic diseases.
This review summarises the latest information about potential therapeutic application of epigenetic modification in targeting immune abnormalities and inflammation of rheumatic diseases.
American Psychological Association (APA)
Ciechomska, Marzena& O’Reilly, Steven. 2016. Epigenetic Modulation as a Therapeutic Prospect for Treatment of Autoimmune Rheumatic Diseases. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111319
Modern Language Association (MLA)
Ciechomska, Marzena& O’Reilly, Steven. Epigenetic Modulation as a Therapeutic Prospect for Treatment of Autoimmune Rheumatic Diseases. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111319
American Medical Association (AMA)
Ciechomska, Marzena& O’Reilly, Steven. Epigenetic Modulation as a Therapeutic Prospect for Treatment of Autoimmune Rheumatic Diseases. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111319