Interleukin-29 Enhances Synovial Inflammation and Cartilage Degradation in Osteoarthritis
Joint Authors
Xu, Lingxiao
Xue, M.
Zhang, Miaojia
Kong, Xiangqing
Peng, Qiuyue
Xuan, Wenhua
Feng, Xiaoke
Tan, Wenfeng
Wang, Fang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
We have recently shown that IL-29 was an important proinflammatory cytokine in pathogenesis of rheumatoid arthritis (RA).
Inflammation also contributes to the pathogenesis of osteoarthritis (OA).
The aim of this study was to investigate the effect and mechanism of IL-29 on cytokine production and cartilage degradation in OA.
The mRNA levels of IL-29 and its specific receptor IL-28Ra in peripheral blood mononuclear cells (PBMCs) were significantly increased in OA patients when compared to healthy controls (HC).
In the serum, IL-29 protein levels were higher in OA patients than those in HC.
Immunohistochemistry revealed that both IL-29 and IL-28Ra were dramatically elevated in OA synovium compared to HC; synovial fibroblasts (FLS) and macrophages were the main IL-29-producing cells in OA synovium.
Furthermore, recombinant IL-29 augmented the mRNA expression of IL-1β, IL-6, IL-8, and matrix-metalloproteinase-3 (MMP-3) in OA FLS and increased cartilage degradation when ex vivo OA cartilage explant was coincubated with OA FLS.
Finally, in OA FLS, IL-29 dominantly activated MAPK and nuclear factor-κB (NF-κB), but not Jak-STAT and AKT signaling pathway as examined by western blot.
In conclusion, IL-29 stimulates inflammation and cartilage degradation by OA FLS, indicating that this cytokine is likely involved in the pathogenesis of OA.
American Psychological Association (APA)
Xu, Lingxiao& Peng, Qiuyue& Xuan, Wenhua& Feng, Xiaoke& Kong, Xiangqing& Zhang, Miaojia…[et al.]. 2016. Interleukin-29 Enhances Synovial Inflammation and Cartilage Degradation in Osteoarthritis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111322
Modern Language Association (MLA)
Xu, Lingxiao…[et al.]. Interleukin-29 Enhances Synovial Inflammation and Cartilage Degradation in Osteoarthritis. Mediators of Inflammation No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1111322
American Medical Association (AMA)
Xu, Lingxiao& Peng, Qiuyue& Xuan, Wenhua& Feng, Xiaoke& Kong, Xiangqing& Zhang, Miaojia…[et al.]. Interleukin-29 Enhances Synovial Inflammation and Cartilage Degradation in Osteoarthritis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111322