NLRP3 Inflammasome Plays an Important Role in the Pathogenesis of Collagen-Induced Arthritis
Joint Authors
Zhang, Yongfeng
Zheng, Yi
Li, Hongbin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To investigate the relationship between NLRP3 and the pathogenesis of collagen-induced arthritis.
Methods.
We used the collagen-induced arthritis (CIA) mouse model.
The mice were divided into two groups: the model group (CIA, n=16) and the control group (Normal, n=8).
The mice were sacrificed seven weeks after immunization.
The arthritis score and imaging evaluation (X-rays, Micro-CT, and MRI) were performed.
Synovial tissue NLRP3 expression and peripheral blood cytokine levels were analyzed.
Results.
The arthritis score (6.00 ± 2.52), imaging score (4.63 ± 0.92), and synovial tissue NLRP3 expression (4.00 ± 2.03) significantly increased in the CIA mice.
The expression of synovial NLRP3 was positively correlated with arthritis clinical and radiographic scores (r=0.792 and r=0.669, resp.).
Conclusions.
The synovial NLRP3 expression increased at the early onset of RA.
Synovial NLRP3 expression level was correlated with the clinical arthritis severity and extent of radiological destruction, suggesting that NLRP3 is involved in the pathogenesis of RA.
American Psychological Association (APA)
Zhang, Yongfeng& Zheng, Yi& Li, Hongbin. 2016. NLRP3 Inflammasome Plays an Important Role in the Pathogenesis of Collagen-Induced Arthritis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1111323
Modern Language Association (MLA)
Zhang, Yongfeng…[et al.]. NLRP3 Inflammasome Plays an Important Role in the Pathogenesis of Collagen-Induced Arthritis. Mediators of Inflammation No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1111323
American Medical Association (AMA)
Zhang, Yongfeng& Zheng, Yi& Li, Hongbin. NLRP3 Inflammasome Plays an Important Role in the Pathogenesis of Collagen-Induced Arthritis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1111323
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111323