Effect of Interleukin-15 on CD11b, CD54, and CD62L Expression on Natural Killer Cell and Natural Killer T-Like Cells in Systemic Lupus Erythematosus
Joint Authors
Kuo, Ming-Ling
Lin, Syh-Jae
Huang, Jing-Long
Chen, Ji-Yih
Hsiao, Hsiu-Shan
Lee, Pei-Tzu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Adhesion molecules may play an important role in systemic lupus erythematosus (SLE) pathogenesis.
We investigated the effect of interleukin- (IL-) 15 on CD11b, CD54, and CD62L expression on natural killer (NK) cells, T cells, and CD56+CD3+ NKT-like cells from SLE subjects and healthy controls.
SLE patients had decreased circulating NK cells and NKT-like cells compared to controls.
NK cells from SLE patients showed higher CD11b and CD62L expression compared to controls.
IL-15 enhanced CD11b and CD54 but downregulated CD62L expression on NK cells from SLE patients.
Similar observations were found for T cells and NKT-like cells.
NK cells from SLE patients expressed higher CD56 than controls; both could be further enhanced by IL-15.
IL-15 also enhanced CD56 expression of NKT-like cells from SLE patients.
A greater degree of IL-15 induced downregulation of CD62L on NKT-like cells noted in SLE patients compared to controls.
The percentage of CD11b expressing NK cells and the % inhibition of CD62L expression on NKT-like cells by IL-15 correlated with serum anti-dsDNA levels in SLE patients, respectively.
Taken together, we demonstrated the dysfunctional NK and NKT-like cells in SLE patients with regard to CD11b and CD62L expression and their response to IL-15.
American Psychological Association (APA)
Lin, Syh-Jae& Chen, Ji-Yih& Kuo, Ming-Ling& Hsiao, Hsiu-Shan& Lee, Pei-Tzu& Huang, Jing-Long. 2016. Effect of Interleukin-15 on CD11b, CD54, and CD62L Expression on Natural Killer Cell and Natural Killer T-Like Cells in Systemic Lupus Erythematosus. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111324
Modern Language Association (MLA)
Lin, Syh-Jae…[et al.]. Effect of Interleukin-15 on CD11b, CD54, and CD62L Expression on Natural Killer Cell and Natural Killer T-Like Cells in Systemic Lupus Erythematosus. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1111324
American Medical Association (AMA)
Lin, Syh-Jae& Chen, Ji-Yih& Kuo, Ming-Ling& Hsiao, Hsiu-Shan& Lee, Pei-Tzu& Huang, Jing-Long. Effect of Interleukin-15 on CD11b, CD54, and CD62L Expression on Natural Killer Cell and Natural Killer T-Like Cells in Systemic Lupus Erythematosus. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111324
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111324