Prognostic Value of Adrenomedullin and Natriuretic Peptides in Uroseptic Patients Induced by Ureteroscopy
Joint Authors
Zhou, Pang-Hu
Hu, Wei
Zhang, Xiao-Bin
Zhang, Li-Jun
Wang, Wei
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of this paper is to investigate whether urosepsis is related to irrigation pressure of ureteroscopy (URS) and evaluate the prognostic value of adrenomedullin (ADM) and atrial and brain natriuretic peptides (ANP and BNP) in URS-induced uroseptic patients.
From July 2008 to October 2013, we enrolled 332 patients with untreated unilateral ureteral obstruction (UUO).
The UUO group included three subgroups of, respectively, 118, 132, and 82 patients who underwent URS under intermittent stable irrigation pressure of, respectively, 80, 120, and 160 mmHg.
The plasma concentrations of ADM, ANP, and BNP were measured in all subjects.
URS was performed for all UUO patients; the values of the three peptides were measured again after URS.
Irrigation pressure and stone size were independent risk factors of urosepsis.
After URS, the plasma concentrations of ADM, ANP, and BNP were significantly higher in uroseptic patients.
Moreover, the concentrations were significantly higher depending on the disease severity.
Plasma concentrations of the three peptides were correlated with plasma ET concentration in the uroseptic patients.
The areas under receiver operating characteristic (ROC) curve of ADM, ANP, and BNP for predicting urosepsis were 0.811, 0.728, and 0.764, respectively.
In conclusion, ADM, along with ANP and BNP, is valuable for prognosis in urosepsis secondary to URS which is associated with irrigation pressure.
American Psychological Association (APA)
Hu, Wei& Zhou, Pang-Hu& Wang, Wei& Zhang, Li-Jun& Zhang, Xiao-Bin. 2016. Prognostic Value of Adrenomedullin and Natriuretic Peptides in Uroseptic Patients Induced by Ureteroscopy. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111325
Modern Language Association (MLA)
Hu, Wei…[et al.]. Prognostic Value of Adrenomedullin and Natriuretic Peptides in Uroseptic Patients Induced by Ureteroscopy. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1111325
American Medical Association (AMA)
Hu, Wei& Zhou, Pang-Hu& Wang, Wei& Zhang, Li-Jun& Zhang, Xiao-Bin. Prognostic Value of Adrenomedullin and Natriuretic Peptides in Uroseptic Patients Induced by Ureteroscopy. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111325
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111325