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Platelet Reactivity Is Independent of Left Atrial Wall Deformation in Patients with Atrial Fibrillation
Joint Authors
Procter, Nathan
Goh, Vincent
Mahadevan, Gnanadevan
Stewart, Simon
Horowitz, John
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
It has been documented recently that left atrial (LA) deformation in AF patients (while in AF) is predictive of subsequent stroke risk.
Additionally, diminished LA deformation during AF correlates with the presence of LA blood stasis.
Given that endothelial function is dependent on laminar blood flow, the present study sought to investigate the effect of diminished LA deformation (during AF) on platelet reactivity and inflammation in AF patients.
Patients ( n = 17 ) hospitalised with AF underwent echocardiography (while in AF) for determination of peak positive LA strain (LASp).
Whole blood impedance aggregometry was used to measure extent of ADP-induced aggregation and subsequent inhibitory response to the nitric oxide (NO) donor, sodium nitroprusside.
Platelet thioredoxin-interacting protein (Txnip) content was determined by immunohistochemistry.
LASp tended ( p = 0.078 ) to vary inversely with CHA2DS2VASc scores.
However, mediators of inflammation (C-reactive protein, Txnip) did not correlate significantly with LASp nor did extent of ADP-induced platelet aggregation or platelet NO response.
These results suggest that the thrombogenic risk associated with LA stasis is independent of secondary effects on platelet aggregability or inflammation.
American Psychological Association (APA)
Procter, Nathan& Goh, Vincent& Mahadevan, Gnanadevan& Stewart, Simon& Horowitz, John. 2016. Platelet Reactivity Is Independent of Left Atrial Wall Deformation in Patients with Atrial Fibrillation. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1111326
Modern Language Association (MLA)
Procter, Nathan…[et al.]. Platelet Reactivity Is Independent of Left Atrial Wall Deformation in Patients with Atrial Fibrillation. Mediators of Inflammation No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1111326
American Medical Association (AMA)
Procter, Nathan& Goh, Vincent& Mahadevan, Gnanadevan& Stewart, Simon& Horowitz, John. Platelet Reactivity Is Independent of Left Atrial Wall Deformation in Patients with Atrial Fibrillation. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1111326
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111326