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When Insult Is Added to Injury: Cross Talk between ILCs and Intestinal Epithelium in IBD
Joint Authors
van der Gracht, Esmé
Zahner, Sonja
Kronenberg, Mitchell
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Inflammatory bowel disease (IBD) is characterized by an impairment of the integrity of the mucosal epithelial barrier, which causes exacerbated inflammation of the intestine.
The intestinal barrier is formed by different specialized epithelial cells, which separate the intestinal lumen from the lamina propria.
In addition to its crucial role in protecting the body from invading pathogens, the intestinal epithelium contributes to intestinal homeostasis by its biochemical properties and communication to underlying immune cells.
Innate lymphoid cells (ILCs) are a recently described population of lymphocytes that have been implicated in both mucosal homeostasis and inflammation.
Recent findings indicate a critical feedback loop in which damaged epithelium activates these innate immune cells to restore epithelial barrier function.
This review will focus on the signalling pathways between damaged epithelium and ILCs involved in repair of the epithelial barrier and tissue homeostasis and the relationship of these processes with the control of IBD.
American Psychological Association (APA)
van der Gracht, Esmé& Zahner, Sonja& Kronenberg, Mitchell. 2016. When Insult Is Added to Injury: Cross Talk between ILCs and Intestinal Epithelium in IBD. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111327
Modern Language Association (MLA)
van der Gracht, Esmé…[et al.]. When Insult Is Added to Injury: Cross Talk between ILCs and Intestinal Epithelium in IBD. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111327
American Medical Association (AMA)
van der Gracht, Esmé& Zahner, Sonja& Kronenberg, Mitchell. When Insult Is Added to Injury: Cross Talk between ILCs and Intestinal Epithelium in IBD. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111327
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111327