Simultaneous Inhibition of PGE2 and PGI2 Signals Is Necessary to Suppress Hyperalgesia in Rat Inflammatory Pain Models
Joint Authors
Sugita, Ryusuke
Kuwabara, Harumi
Kubota, Kazufumi
Sugimoto, Kotaro
Kiho, Toshihiro
Tengeiji, Atsushi
Kawakami, Katsuhiro
Shimada, Kohei
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Prostaglandin E2 (PGE2) is well known as a mediator of inflammatory symptoms such as fever, arthritis, and inflammatory pain.
In the present study, we evaluated the analgesic effect of our selective PGE2 synthesis inhibitor, compound I, 2-methyl-2-[cis-4-([1-(6-methyl-3-phenylquinolin-2-yl)piperidin-4-yl]carbonyl amino)cyclohexyl] propanoic acid, in rat yeast-induced acute and adjuvant-induced chronic inflammatory pain models.
Although this compound suppressed the synthesis of PGE2 selectively, no analgesic effect was shown in both inflammatory pain models.
Prostacyclin (PGI2) also plays crucial roles in inflammatory pain, so we evaluated the involvement of PGI2 signaling in rat inflammatory pain models using prostacyclin receptor (IP) antagonist, RO3244019.
RO3244019 showed no analgesic effect in inflammatory pain models, but concomitant administration of compound I and RO3244019 showed analgesic effects comparable to celecoxib, a specific cyclooxygenase- (COX-) 2 inhibitor.
Furthermore, coadministration of PGE2 receptor 4 (EP4) antagonist, CJ-023423, and RO3244019 also showed an analgesic effect.
These findings suggest that both PGE2 signaling, especially through the EP4 receptor, and PGI2 signaling play critical roles in inflammatory pain and concurrent inhibition of both signals is important for suppression of inflammatory hyperalgesia.
American Psychological Association (APA)
Sugita, Ryusuke& Kuwabara, Harumi& Kubota, Kazufumi& Sugimoto, Kotaro& Kiho, Toshihiro& Tengeiji, Atsushi…[et al.]. 2016. Simultaneous Inhibition of PGE2 and PGI2 Signals Is Necessary to Suppress Hyperalgesia in Rat Inflammatory Pain Models. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111332
Modern Language Association (MLA)
Sugita, Ryusuke…[et al.]. Simultaneous Inhibition of PGE2 and PGI2 Signals Is Necessary to Suppress Hyperalgesia in Rat Inflammatory Pain Models. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1111332
American Medical Association (AMA)
Sugita, Ryusuke& Kuwabara, Harumi& Kubota, Kazufumi& Sugimoto, Kotaro& Kiho, Toshihiro& Tengeiji, Atsushi…[et al.]. Simultaneous Inhibition of PGE2 and PGI2 Signals Is Necessary to Suppress Hyperalgesia in Rat Inflammatory Pain Models. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111332
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111332