Astrocyte Hypertrophy Contributes to Aberrant Neurogenesis after Traumatic Brain Injury
Joint Authors
Robinson, Clark
Apgar, Christopher
Shapiro, Lee A.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Traumatic brain injury (TBI) is a widespread epidemic with severe cognitive, affective, and behavioral consequences.
TBIs typically result in a relatively rapid inflammatory and neuroinflammatory response.
A major component of the neuroinflammatory response is astrocytes, a type of glial cell in the brain.
Astrocytes are important in maintaining the integrity of neuronal functioning, and it is possible that astrocyte hypertrophy after TBIs might contribute to pathogenesis.
The hippocampus is a unique brain region, because neurogenesis persists in adults.
Accumulating evidence supports the functional importance of these newborn neurons and their associated astrocytes.
Alterations to either of these cell types can influence neuronal functioning.
To determine if hypertrophied astrocytes might negatively influence immature neurons in the dentate gyrus, astrocyte and newborn neurons were analyzed at 30 days following a TBI in mice.
The results demonstrate a loss of radial glial-like processes extending through the granule cell layer after TBI, as well as ectopic growth and migration of immature dentate neurons.
The results further show newborn neurons in close association with hypertrophied astrocytes, suggesting a role for the astrocytes in aberrant neurogenesis.
Future studies are needed to determine the functional significance of these alterations to the astrocyte/immature neurons after TBI.
American Psychological Association (APA)
Robinson, Clark& Apgar, Christopher& Shapiro, Lee A.. 2016. Astrocyte Hypertrophy Contributes to Aberrant Neurogenesis after Traumatic Brain Injury. Neural Plasticity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1112970
Modern Language Association (MLA)
Robinson, Clark…[et al.]. Astrocyte Hypertrophy Contributes to Aberrant Neurogenesis after Traumatic Brain Injury. Neural Plasticity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1112970
American Medical Association (AMA)
Robinson, Clark& Apgar, Christopher& Shapiro, Lee A.. Astrocyte Hypertrophy Contributes to Aberrant Neurogenesis after Traumatic Brain Injury. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1112970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1112970