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Eyes Open on Sleep and Wake: In Vivo to In Silico Neural Networks
Joint Authors
Phillips, Christophe
Vanvinckenroye, Amaury
Vandewalle, Gilles
Chellappa, Sarah L.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Functional and effective connectivity of cortical areas are essential for normal brain function under different behavioral states.
Appropriate cortical activity during sleep and wakefulness is ensured by the balanced activity of excitatory and inhibitory circuits.
Ultimately, fast, millisecond cortical rhythmic oscillations shape cortical function in time and space.
On a much longer time scale, brain function also depends on prior sleep-wake history and circadian processes.
However, much remains to be established on how the brain operates at the neuronal level in humans during sleep and wakefulness.
A key limitation of human neuroscience is the difficulty in isolating neuronal excitation/inhibition drive in vivo.
Therefore, computational models are noninvasive approaches of choice to indirectly access hidden neuronal states.
In this review, we present a physiologically driven in silico approach, Dynamic Causal Modelling (DCM), as a means to comprehend brain function under different experimental paradigms.
Importantly, DCM has allowed for the understanding of how brain dynamics underscore brain plasticity, cognition, and different states of consciousness.
In a broader perspective, noninvasive computational approaches, such as DCM, may help to puzzle out the spatial and temporal dynamics of human brain function at different behavioural states.
American Psychological Association (APA)
Vanvinckenroye, Amaury& Vandewalle, Gilles& Phillips, Christophe& Chellappa, Sarah L.. 2016. Eyes Open on Sleep and Wake: In Vivo to In Silico Neural Networks. Neural Plasticity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1112973
Modern Language Association (MLA)
Vanvinckenroye, Amaury…[et al.]. Eyes Open on Sleep and Wake: In Vivo to In Silico Neural Networks. Neural Plasticity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1112973
American Medical Association (AMA)
Vanvinckenroye, Amaury& Vandewalle, Gilles& Phillips, Christophe& Chellappa, Sarah L.. Eyes Open on Sleep and Wake: In Vivo to In Silico Neural Networks. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1112973
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1112973