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Resting-State Functional Connectivity and Cognitive Impairment in Children with Perinatal Stroke
Joint Authors
Ilves, Nigul
Ilves, Pilvi
Laugesaar, Rael
Juurmaa, Julius
Männamaa, Mairi
Lõo, Silva
Loorits, Dagmar
Tomberg, Tiiu
Kolk, Anneli
Talvik, Inga
Talvik, Tiina
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Perinatal stroke is a leading cause of congenital hemiparesis and neurocognitive deficits in children.
Dysfunctions in the large-scale resting-state functional networks may underlie cognitive and behavioral disability in these children.
We studied resting-state functional connectivity in patients with perinatal stroke collected from the Estonian Pediatric Stroke Database.
Neurodevelopment of children was assessed by the Pediatric Stroke Outcome Measurement and the Kaufman Assessment Battery.
The study included 36 children (age range 7.6–17.9 years): 10 with periventricular venous infarction (PVI), 7 with arterial ischemic stroke (AIS), and 19 controls.
There were no differences in severity of hemiparesis between the PVI and AIS groups.
A significant increase in default mode network connectivity (FDR 0.1) and lower cognitive functions ( p < 0.05 ) were found in children with AIS compared to the controls and the PVI group.
The children with PVI had no significant differences in the resting-state networks compared to the controls and their cognitive functions were normal.
Our findings demonstrate impairment in cognitive functions and neural network profile in hemiparetic children with AIS compared to children with PVI and controls.
Changes in the resting-state networks found in children with AIS could possibly serve as the underlying derangements of cognitive brain functions in these children.
American Psychological Association (APA)
Ilves, Nigul& Ilves, Pilvi& Laugesaar, Rael& Juurmaa, Julius& Männamaa, Mairi& Lõo, Silva…[et al.]. 2016. Resting-State Functional Connectivity and Cognitive Impairment in Children with Perinatal Stroke. Neural Plasticity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113015
Modern Language Association (MLA)
Ilves, Nigul…[et al.]. Resting-State Functional Connectivity and Cognitive Impairment in Children with Perinatal Stroke. Neural Plasticity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113015
American Medical Association (AMA)
Ilves, Nigul& Ilves, Pilvi& Laugesaar, Rael& Juurmaa, Julius& Männamaa, Mairi& Lõo, Silva…[et al.]. Resting-State Functional Connectivity and Cognitive Impairment in Children with Perinatal Stroke. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113015
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113015