Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease
Joint Authors
Stefen, Holly
Chaichim, Chanchanok
Power, John
Fath, Thomas
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-05
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Disruption of synaptic function at excitatory synapses is one of the earliest pathological changes seen in wide range of neurological diseases.
The proper control of the segregation of neurotransmitter receptors at these synapses is directly correlated with the intact regulation of the postsynaptic cytoskeleton.
In this review, we are discussing key factors that regulate the structure and dynamics of the actin cytoskeleton, the major cytoskeletal building block that supports the postsynaptic compartment.
Special attention is given to the complex interplay of actin-associated proteins that are found in the synaptic specialization.
We then discuss our current understanding of how disruption of these cytoskeletal elements may contribute to the pathological events observed in the nervous system under disease conditions with a particular focus on Alzheimer’s disease pathology.
American Psychological Association (APA)
Stefen, Holly& Chaichim, Chanchanok& Power, John& Fath, Thomas. 2016. Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease. Neural Plasticity،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1113020
Modern Language Association (MLA)
Stefen, Holly…[et al.]. Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease. Neural Plasticity No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1113020
American Medical Association (AMA)
Stefen, Holly& Chaichim, Chanchanok& Power, John& Fath, Thomas. Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1113020
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113020