Lipidomic Analysis of Endocannabinoid Signaling: Targeted Metabolite Identification and Quantification
Joint Authors
Keereetaweep, Jantana
Chapman, Kent D.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The endocannabinoids N-arachidonoylethanolamide (or anandamide, AEA) and 2-arachidonoylglycerol (2-AG) belong to the larger groups of N-acylethanolamines (NAEs) and monoacylglycerol (MAG) lipid classes, respectively.
They are biologically active lipid molecules that activate G-protein-coupled cannabinoid receptors found in various organisms.
After AEA and 2-AG were discovered in the 1990s, they have been extensively documented to have a broad range of physiological functions.
Along with AEA, several NAEs, for example, N-palmitoylethanolamine (PEA), N-stearoylethanolamine (SEA), and N-oleoylethanolamine (OEA) are also present in tissues, usually at much larger concentrations than AEA.
Any perturbation that involves the endocannabinoid pathway may subsequently alter basal level or metabolism of these lipid mediators.
Further, the altered levels of these molecules often reflect pathological conditions associated with tissue damage.
Robust and sensitive methodologies to analyze these lipid mediators are essential to understanding how they act as endocannabinoids.
The recent advances in mass spectrometry allow researchers to develop lipidomics approaches and several methodologies have been proposed to quantify endocannabinoids in various biological systems.
American Psychological Association (APA)
Keereetaweep, Jantana& Chapman, Kent D.. 2015. Lipidomic Analysis of Endocannabinoid Signaling: Targeted Metabolite Identification and Quantification. Neural Plasticity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113022
Modern Language Association (MLA)
Keereetaweep, Jantana& Chapman, Kent D.. Lipidomic Analysis of Endocannabinoid Signaling: Targeted Metabolite Identification and Quantification. Neural Plasticity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1113022
American Medical Association (AMA)
Keereetaweep, Jantana& Chapman, Kent D.. Lipidomic Analysis of Endocannabinoid Signaling: Targeted Metabolite Identification and Quantification. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113022
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113022