Differential DNA Methylation of MicroRNA Genes in Temporal Cortex from Alzheimer’s Disease Individuals
Joint Authors
Villela, Darine
Grinberg, Lea Tenenholz
Brentani, Helena Paula
Rosenberg, Carla
Krepischi, Ana C. V.
Ramalho, Rodrigo F.
Silva, Aderbal R. T.
Suemoto, Claudia K.
Pasqualucci, Carlos Augusto
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study investigated for the first time the genomewide DNA methylation changes of noncoding RNA genes in the temporal cortex samples from individuals with Alzheimer’s disease (AD).
The methylome of 10 AD individuals and 10 age-matched controls were obtained using Illumina 450 K methylation array.
A total of 2,095 among the 15,258 interrogated noncoding RNA CpG sites presented differential methylation, 161 of which were associated with miRNA genes.
In particular, 10 miRNA CpG sites that were found to be hypermethylated in AD compared to control brains represent transcripts that have been previously associated with the disease.
This miRNA set is predicted to target 33 coding genes from the neuregulin receptor complex (ErbB) signaling pathway, which is required for the neurons myelination process.
For 6 of these miRNA genes (MIR9-1, MIR9-3, MIR181C, MIR124-1, MIR146B, and MIR451), the hypermethylation pattern is in agreement with previous results from literature that shows downregulation of miR-9, miR-181c, miR-124, miR-146b, and miR-451 in the AD brain.
Our data implicate dysregulation of miRNA methylation as contributor to the pathogenesis of AD.
American Psychological Association (APA)
Villela, Darine& Ramalho, Rodrigo F.& Silva, Aderbal R. T.& Brentani, Helena Paula& Suemoto, Claudia K.& Pasqualucci, Carlos Augusto…[et al.]. 2016. Differential DNA Methylation of MicroRNA Genes in Temporal Cortex from Alzheimer’s Disease Individuals. Neural Plasticity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113028
Modern Language Association (MLA)
Villela, Darine…[et al.]. Differential DNA Methylation of MicroRNA Genes in Temporal Cortex from Alzheimer’s Disease Individuals. Neural Plasticity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113028
American Medical Association (AMA)
Villela, Darine& Ramalho, Rodrigo F.& Silva, Aderbal R. T.& Brentani, Helena Paula& Suemoto, Claudia K.& Pasqualucci, Carlos Augusto…[et al.]. Differential DNA Methylation of MicroRNA Genes in Temporal Cortex from Alzheimer’s Disease Individuals. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113028