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Neuromodulator and Emotion Biomarker for Stress Induced Mental Disorders
Joint Authors
Wang, Fushun
Huang, Jason H.
Gu, Simeng
Wang, Wei
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Affective disorders are a leading cause of disabilities worldwide, and the etiology of these many affective disorders such as depression and posttraumatic stress disorder is due to hormone changes, which includes hypothalamus-pituitary-adrenal axis in the peripheral nervous system and neuromodulators in the central nervous system.
Consistent with pharmacological studies indicating that medical treatment acts by increasing the concentration of catecholamine, the locus coeruleus (LC)/norepinephrine (NE) system is regarded as a critical part of the central “stress circuitry,” whose major function is to induce “fight or flight” behavior and fear and anger emotion.
Despite the intensive studies, there is still controversy about NE with fear and anger.
For example, the rats with LC ablation were more reluctant to leave a familiar place and took longer to consume the food pellets in an unfamiliar place (neophobia, i.e., fear in response to novelty).
The reason for this discrepancy might be that NE is not only for flight (fear), but also for fight (anger).
Here, we try to review recent literatures about NE with stress induced emotions and their relations with mental disorders.
We propose that stress induced NE release can induce both fear and anger.
“Adrenaline rush or norepinephrine rush” and fear and anger emotion might act as biomarkers for mental disorders.
American Psychological Association (APA)
Gu, Simeng& Wang, Wei& Wang, Fushun& Huang, Jason H.. 2016. Neuromodulator and Emotion Biomarker for Stress Induced Mental Disorders. Neural Plasticity،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1113031
Modern Language Association (MLA)
Gu, Simeng…[et al.]. Neuromodulator and Emotion Biomarker for Stress Induced Mental Disorders. Neural Plasticity No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1113031
American Medical Association (AMA)
Gu, Simeng& Wang, Wei& Wang, Fushun& Huang, Jason H.. Neuromodulator and Emotion Biomarker for Stress Induced Mental Disorders. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1113031
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113031