Interpreting Intervention Induced Neuroplasticity with fMRI: The Case for Multimodal Imaging Strategies
Joint Authors
Reid, Lee B.
Cunnington, Ross
Rose, Stephen E.
Boyd, Roslyn N.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Direct measurement of recovery from brain injury is an important goal in neurorehabilitation, and requires reliable, objective, and interpretable measures of changes in brain function, referred to generally as “neuroplasticity.” One popular imaging modality for measuring neuroplasticity is task-based functional magnetic resonance imaging (t-fMRI).
In the field of neurorehabilitation, however, assessing neuroplasticity using t-fMRI presents a significant challenge.
This commentary reviews t-fMRI changes commonly reported in patients with cerebral palsy or acquired brain injuries, with a focus on studies of motor rehabilitation, and discusses complexities surrounding their interpretations.
Specifically, we discuss the difficulties in interpreting t-fMRI changes in terms of their underlying causes, that is, differentiating whether they reflect genuine reorganisation, neurological restoration, compensation, use of preexisting redundancies, changes in strategy, or maladaptive processes.
Furthermore, we discuss the impact of heterogeneous disease states and essential t-fMRI processing steps on the interpretability of activation patterns.
To better understand therapy-induced neuroplastic changes, we suggest that researchers utilising t-fMRI consider concurrently acquiring information from an additional modality, to quantify, for example, haemodynamic differences or microstructural changes.
We outline a variety of such supplementary measures for investigating brain reorganisation and discuss situations in which they may prove beneficial to the interpretation of t-fMRI data.
American Psychological Association (APA)
Reid, Lee B.& Boyd, Roslyn N.& Cunnington, Ross& Rose, Stephen E.. 2015. Interpreting Intervention Induced Neuroplasticity with fMRI: The Case for Multimodal Imaging Strategies. Neural Plasticity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113032
Modern Language Association (MLA)
Reid, Lee B.…[et al.]. Interpreting Intervention Induced Neuroplasticity with fMRI: The Case for Multimodal Imaging Strategies. Neural Plasticity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1113032
American Medical Association (AMA)
Reid, Lee B.& Boyd, Roslyn N.& Cunnington, Ross& Rose, Stephen E.. Interpreting Intervention Induced Neuroplasticity with fMRI: The Case for Multimodal Imaging Strategies. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113032
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113032