Brain Connectomics’ Modification to Clarify Motor and Nonmotor Features of Myotonic Dystrophy Type 1
Joint Authors
Carlo, Caltagirone
Meola, Giovanni
Serra, Laura
Mancini, Matteo
Silvestri, Gabriella
Petrucci, Antonio
Masciullo, Marcella
Spanò, Barbara
Torso, Mario
Mastropasqua, Chiara
Giacanelli, Manlio
Cercignani, Mara
Bozzali, Marco
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The adult form of myotonic dystrophy type 1 (DM1) presents with paradoxical inconsistencies between severity of brain damage, relative preservation of cognition, and failure in everyday life.
This study, based on the assessment of brain connectivity and mechanisms of plasticity, aimed at reconciling these conflicting issues.
Resting-state functional MRI and graph theoretical methods of analysis were used to assess brain topological features in a large cohort of patients with DM1.
Patients, compared to controls, revealed reduced connectivity in a large frontoparietal network that correlated with their isolated impairment in visuospatial reasoning.
Despite a global preservation of the topological properties, peculiar patterns of frontal disconnection and increased parietal-cerebellar connectivity were also identified in patients’ brains.
The balance between loss of connectivity and compensatory mechanisms in different brain networks might explain the paradoxical mismatch between structural brain damage and minimal cognitive deficits observed in these patients.
This study provides a comprehensive assessment of brain abnormalities that fit well with both motor and nonmotor clinical features experienced by patients in their everyday life.
The current findings suggest that measures of functional connectivity may offer the possibility of characterizing individual patients with the potential to become a clinical tool.
American Psychological Association (APA)
Serra, Laura& Mancini, Matteo& Silvestri, Gabriella& Petrucci, Antonio& Masciullo, Marcella& Spanò, Barbara…[et al.]. 2016. Brain Connectomics’ Modification to Clarify Motor and Nonmotor Features of Myotonic Dystrophy Type 1. Neural Plasticity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113034
Modern Language Association (MLA)
Serra, Laura…[et al.]. Brain Connectomics’ Modification to Clarify Motor and Nonmotor Features of Myotonic Dystrophy Type 1. Neural Plasticity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113034
American Medical Association (AMA)
Serra, Laura& Mancini, Matteo& Silvestri, Gabriella& Petrucci, Antonio& Masciullo, Marcella& Spanò, Barbara…[et al.]. Brain Connectomics’ Modification to Clarify Motor and Nonmotor Features of Myotonic Dystrophy Type 1. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113034
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113034