Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies
Joint Authors
Carvajal, Francisco J.
Mattison, Hayley A.
Cerpa, Waldo
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-18
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
N-Methyl-D-aspartate receptors (NMDARs) have two opposing roles in the brain.
On the one hand, NMDARs control critical events in the formation and development of synaptic organization and synaptic plasticity.
On the other hand, the overactivation of NMDARs can promote neuronal death in neuropathological conditions.
Ca2+ influx acts as a primary modulator after NMDAR channel activation.
An imbalance in Ca2+ homeostasis is associated with several neurological diseases including schizophrenia, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis.
These chronic conditions have a lengthy progression depending on internal and external factors.
External factors such as acute episodes of brain damage are associated with an earlier onset of several of these chronic mental conditions.
Here, we will review some of the current evidence of how traumatic brain injury can hasten the onset of several neurological conditions, focusing on the role of NMDAR distribution and the functional consequences in calcium homeostasis associated with synaptic dysfunction and neuronal death present in this group of chronic diseases.
American Psychological Association (APA)
Carvajal, Francisco J.& Mattison, Hayley A.& Cerpa, Waldo. 2016. Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies. Neural Plasticity،Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1113035
Modern Language Association (MLA)
Carvajal, Francisco J.…[et al.]. Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies. Neural Plasticity No. 2016 (2016), pp.1-20.
https://search.emarefa.net/detail/BIM-1113035
American Medical Association (AMA)
Carvajal, Francisco J.& Mattison, Hayley A.& Cerpa, Waldo. Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1113035
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113035