Behavioral Deficits in Juveniles Mediated by Maternal Stress Hormones in Mice
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Maternal depression has been shown to negatively impact offspring development.
Investigation into the impact of maternal depression and offspring behavior has relied on correlative studies in humans.
Further investigation into the underlying mechanisms has been hindered by the lack of useful animal models.
We previously characterized a mouse model which exhibits depression-like behaviors restricted to the postpartum period and abnormal/fragmented maternal care (Gabrd−/− mice).
Here we utilized this unique mouse model to investigate the mechanism(s) through which maternal depression-like behaviors adversely impact offspring development.
Cross-fostering experiments reveal increased anxiety-like and depression-like behaviors in mice reared by Gabrd−/− mothers.
Wild type and Gabrd−/− mice subjected to unpredictable stress during late pregnancy exhibit decreased pup survival and depression-like behavior in the postpartum period.
Exogenous corticosterone treatment in wild type mice during late pregnancy is sufficient to decrease pup survival and induce anxiety-like and depression-like behaviors in the offspring.
Further, the abnormal behaviors in juvenile mice reared by Gabrd−/− mice are alleviated by treatment of the mothers with the corticotropin-releasing hormone (CRH) antagonist, Antalarmin.
These studies suggest that hyperresponsiveness of the HPA axis is associated with postpartum depression and may mediate the adverse effects of maternal depression on offspring behavior.
American Psychological Association (APA)
Maguire, Jamie& Mody, Istvan. 2015. Behavioral Deficits in Juveniles Mediated by Maternal Stress Hormones in Mice. Neural Plasticity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113040
Modern Language Association (MLA)
Maguire, Jamie& Mody, Istvan. Behavioral Deficits in Juveniles Mediated by Maternal Stress Hormones in Mice. Neural Plasticity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1113040
American Medical Association (AMA)
Maguire, Jamie& Mody, Istvan. Behavioral Deficits in Juveniles Mediated by Maternal Stress Hormones in Mice. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113040
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113040