The Endocannabinoid System in the Retina: From Physiology to Practical and Therapeutic Applications
Joint Authors
Schwitzer, Thomas
Schwan, Raymund
Angioi-Duprez, Karine
Giersch, Anne
Laprevote, Vincent
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cannabis is one of the most prevalent drugs used in industrialized countries.
The main effects of Cannabis are mediated by two major exogenous cannabinoids: ∆9-tetrahydroxycannabinol and cannabidiol.
They act on specific endocannabinoid receptors, especially types 1 and 2.
Mammals are endowed with a functional cannabinoid system including cannabinoid receptors, ligands, and enzymes.
This endocannabinoid signaling pathway is involved in both physiological and pathophysiological conditions with a main role in the biology of the central nervous system.
As the retina is a part of the central nervous system due to its embryonic origin, we aim at providing the relevance of studying the endocannabinoid system in the retina.
Here, we review the distribution of the cannabinoid receptors, ligands, and enzymes in the retina and focus on the role of the cannabinoid system in retinal neurobiology.
This review describes the presence of the cannabinoid system in critical stages of retinal processing and its broad involvement in retinal neurotransmission, neuroplasticity, and neuroprotection.
Accordingly, we support the use of synthetic cannabinoids as new neuroprotective drugs to prevent and treat retinal diseases.
Finally, we argue for the relevance of functional retinal measures in cannabis users to evaluate the impact of cannabis use on human retinal processing.
American Psychological Association (APA)
Schwitzer, Thomas& Schwan, Raymund& Angioi-Duprez, Karine& Giersch, Anne& Laprevote, Vincent. 2016. The Endocannabinoid System in the Retina: From Physiology to Practical and Therapeutic Applications. Neural Plasticity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113047
Modern Language Association (MLA)
Schwitzer, Thomas…[et al.]. The Endocannabinoid System in the Retina: From Physiology to Practical and Therapeutic Applications. Neural Plasticity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113047
American Medical Association (AMA)
Schwitzer, Thomas& Schwan, Raymund& Angioi-Duprez, Karine& Giersch, Anne& Laprevote, Vincent. The Endocannabinoid System in the Retina: From Physiology to Practical and Therapeutic Applications. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113047
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113047