Direct Spinal Ventral Root Repair following Avulsion: Effectiveness of a New Heterologous Fibrin Sealant on Motoneuron Survival and Regeneration
Joint Authors
Vidigal de Castro, Mateus
Barbizan, Roberta
Seabra Ferreira, Rui
Leite Rodrigues de Oliveira, Alexandre
Barraviera, B.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-24
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Axonal injuries at the interface between central and peripheral nervous system, such as ventral root avulsion (VRA), induce important degenerative processes, mostly resulting in neuronal and motor function loss.
In the present work, we have compared two different fibrin sealants, one derived from human blood and another derived from animal blood and Crotalus durissus terrificus venom, as a promising treatment for this type of injury.
Lewis rats were submitted to VRA (L4–L6) and had the avulsed roots reimplanted to the surface of the spinal cord, with the aid of fibrin sealant.
The spinal cords were processed to evaluate neuronal survival, synaptic stability, and glial reactivity, 4 and 12 weeks after lesion.
Sciatic nerves were processed to investigate Schwann cell activity by p 75 NTR expression (4 weeks after surgery) and to count myelinated axons and morphometric evaluation (12 weeks after surgery).
Walking track test was used to evaluate gait recovery, up to 12 weeks.
The results indicate that both fibrin sealants are similarly efficient.
However, the snake-derived fibrin glue is a potentially safer alternative for being a biological and biodegradable product which does not contain human blood derivatives.
Therefore, the venom glue can be a useful tool for the scientific community due to its advantages and variety of applications.
American Psychological Association (APA)
Vidigal de Castro, Mateus& Barbizan, Roberta& Seabra Ferreira, Rui& Barraviera, B.& Leite Rodrigues de Oliveira, Alexandre. 2016. Direct Spinal Ventral Root Repair following Avulsion: Effectiveness of a New Heterologous Fibrin Sealant on Motoneuron Survival and Regeneration. Neural Plasticity،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113048
Modern Language Association (MLA)
Vidigal de Castro, Mateus…[et al.]. Direct Spinal Ventral Root Repair following Avulsion: Effectiveness of a New Heterologous Fibrin Sealant on Motoneuron Survival and Regeneration. Neural Plasticity No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1113048
American Medical Association (AMA)
Vidigal de Castro, Mateus& Barbizan, Roberta& Seabra Ferreira, Rui& Barraviera, B.& Leite Rodrigues de Oliveira, Alexandre. Direct Spinal Ventral Root Repair following Avulsion: Effectiveness of a New Heterologous Fibrin Sealant on Motoneuron Survival and Regeneration. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113048
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113048