Multilevel Deficiency of White Matter Connectivity Networks in Alzheimer’s Disease: A Diffusion MRI Study with DTI and HARDI Models
Joint Authors
Wang, Tao
Shi, Feng
Jin, Yan
Yap, Pew-Thian
Wee, Chong-Yaw
Zhang, Jianye
Yang, Cece
Li, Xia
Xiao, Shifu
Shen, Dinggang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-13
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is the most common form of dementia in elderly people.
It is an irreversible and progressive brain disease.
In this paper, we utilized diffusion-weighted imaging (DWI) to detect abnormal topological organization of white matter (WM) structural networks.
We compared the differences between WM connectivity characteristics at global, regional, and local levels in 26 patients with probable AD and 16 normal control (NC) elderly subjects, using connectivity networks constructed with the diffusion tensor imaging (DTI) model and the high angular resolution diffusion imaging (HARDI) model, respectively.
At the global level, we found that the WM structural networks of both AD and NC groups had a small-world topology; however, the AD group showed a significant decrease in both global and local efficiency, but an increase in clustering coefficient and the average shortest path length.
We further found that the AD patients had significantly decreased nodal efficiency at the regional level, as well as weaker connections in multiple local cortical and subcortical regions, such as precuneus, temporal lobe, hippocampus, and thalamus.
The HARDI model was found to be more advantageous than the DTI model, as it was more sensitive to the deficiencies in AD at all of the three levels.
American Psychological Association (APA)
Wang, Tao& Shi, Feng& Jin, Yan& Yap, Pew-Thian& Wee, Chong-Yaw& Zhang, Jianye…[et al.]. 2016. Multilevel Deficiency of White Matter Connectivity Networks in Alzheimer’s Disease: A Diffusion MRI Study with DTI and HARDI Models. Neural Plasticity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113050
Modern Language Association (MLA)
Wang, Tao…[et al.]. Multilevel Deficiency of White Matter Connectivity Networks in Alzheimer’s Disease: A Diffusion MRI Study with DTI and HARDI Models. Neural Plasticity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1113050
American Medical Association (AMA)
Wang, Tao& Shi, Feng& Jin, Yan& Yap, Pew-Thian& Wee, Chong-Yaw& Zhang, Jianye…[et al.]. Multilevel Deficiency of White Matter Connectivity Networks in Alzheimer’s Disease: A Diffusion MRI Study with DTI and HARDI Models. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113050
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113050