Radiation-Induced Growth Retardation and Microstructural and Metabolite Abnormalities in the Hippocampus
Joint Authors
Leasure, J. Leigh
Zawaski, Janice A.
Sahnoune, Iman
Gaber, M. Waleed
Rodgers, Shaefali P.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cranial radiotherapy (CRT) increases survival in pediatric brain-tumor patients but can cause deleterious effects.
This study evaluates the acute and long-term impact of CRT delivered during childhood/adolescence on the brain and body using a rodent model.
Rats received CRT, either 4 Gy fractions × 5 d (fractionated) or a cumulative dose of 20 Gy (single dose) at 28 d of age.
Animals were euthanized 1 d, 5 d, or 3.5 mo after CRT.
The 3.5 mo group was imaged prior to euthanasia.
At 3.5 mo, we observed significant growth retardation in irradiated animals, versus controls, and the effects of single dose on brain and body weights were more severe than fractionated.
Acutely single dose significantly reduced body weight but increased brain weight, whereas fractionation significantly reduced brain but not body weights, versus controls.
CRT suppressed cell proliferation in the hippocampal subgranular zone acutely.
Fractional anisotropy (FA) in the fimbria was significantly lower in the single dose versus controls.
Hippocampal metabolite levels were significantly altered in the single dose animals, reflecting a heightened state of inflammation that was absent in the fractionated.
Our findings indicate that despite the differences in severity between the doses they both demonstrated an effect on cell proliferation and growth retardation, important factors in pediatric CRT.
American Psychological Association (APA)
Rodgers, Shaefali P.& Zawaski, Janice A.& Sahnoune, Iman& Leasure, J. Leigh& Gaber, M. Waleed. 2016. Radiation-Induced Growth Retardation and Microstructural and Metabolite Abnormalities in the Hippocampus. Neural Plasticity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113071
Modern Language Association (MLA)
Rodgers, Shaefali P.…[et al.]. Radiation-Induced Growth Retardation and Microstructural and Metabolite Abnormalities in the Hippocampus. Neural Plasticity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113071
American Medical Association (AMA)
Rodgers, Shaefali P.& Zawaski, Janice A.& Sahnoune, Iman& Leasure, J. Leigh& Gaber, M. Waleed. Radiation-Induced Growth Retardation and Microstructural and Metabolite Abnormalities in the Hippocampus. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113071