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Dysfunction in Ribosomal Gene Expression in the Hypothalamus and Hippocampus following Chronic Social Defeat Stress in Male Mice as Revealed by RNA-Seq
Joint Authors
Orlov, Yuriy L.
Smagin, Dmitry A.
Kovalenko, Irina L.
Galyamina, Anna G.
Bragin, Anatoly O.
Kudryavtseva, Natalia N.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Chronic social defeat stress leads to the development of anxiety- and depression-like states in male mice and is accompanied by numerous molecular changes in brain.
The influence of 21-day period of social stress on ribosomal gene expression in five brain regions was studied using the RNA-Seq database.
Most Rps, Rpl, Mprs, and Mprl genes were upregulated in the hypothalamus and downregulated in the hippocampus, which may indicate ribosomal dysfunction following chronic social defeat stress.
There were no differentially expressed ribosomal genes in the ventral tegmental area, midbrain raphe nuclei, or striatum.
This approach may be used to identify a pharmacological treatment of ribosome biogenesis abnormalities in the brain of patients with “ribosomopathies.”
American Psychological Association (APA)
Smagin, Dmitry A.& Kovalenko, Irina L.& Galyamina, Anna G.& Bragin, Anatoly O.& Orlov, Yuriy L.& Kudryavtseva, Natalia N.. 2015. Dysfunction in Ribosomal Gene Expression in the Hypothalamus and Hippocampus following Chronic Social Defeat Stress in Male Mice as Revealed by RNA-Seq. Neural Plasticity،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1113073
Modern Language Association (MLA)
Smagin, Dmitry A.…[et al.]. Dysfunction in Ribosomal Gene Expression in the Hypothalamus and Hippocampus following Chronic Social Defeat Stress in Male Mice as Revealed by RNA-Seq. Neural Plasticity No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1113073
American Medical Association (AMA)
Smagin, Dmitry A.& Kovalenko, Irina L.& Galyamina, Anna G.& Bragin, Anatoly O.& Orlov, Yuriy L.& Kudryavtseva, Natalia N.. Dysfunction in Ribosomal Gene Expression in the Hypothalamus and Hippocampus following Chronic Social Defeat Stress in Male Mice as Revealed by RNA-Seq. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1113073
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113073