Topological Properties of Large-Scale Cortical Networks Based on Multiple Morphological Features in Amnestic Mild Cognitive Impairment
Joint Authors
Li, Shuyu
Han, Ying
Li, Kuncheng
Li, Qiongling
Li, Xinwei
Wang, Xuetong
Li, Yuxia
Yu, Yang
Yin, Changhao
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Previous studies have demonstrated that amnestic mild cognitive impairment (aMCI) has disrupted properties of large-scale cortical networks based on cortical thickness and gray matter volume.
However, it is largely unknown whether the topological properties of cortical networks based on geometric measures (i.e., sulcal depth, curvature, and metric distortion) change in aMCI patients compared with normal controls because these geometric features of cerebral cortex may be related to its intrinsic connectivity.
Here, we compare properties in cortical networks constructed by six different morphological features in 36 aMCI participants and 36 normal controls.
Six cortical features (3 volumetric and 3 geometric features) were extracted for each participant, and brain abnormities in aMCI were identified by cortical network based on graph theory method.
All the cortical networks showed small-world properties.
Regions showing significant differences mainly located in the medial temporal lobe and supramarginal and right inferior parietal lobe.
In addition, we also found that the cortical networks constructed by cortical thickness and sulcal depth showed significant differences between the two groups.
Our results indicated that geometric measure (i.e., sulcal depth) can be used to construct network to discriminate individuals with aMCI from controls besides volumetric measures.
American Psychological Association (APA)
Li, Qiongling& Li, Xinwei& Wang, Xuetong& Li, Yuxia& Li, Kuncheng& Yu, Yang…[et al.]. 2016. Topological Properties of Large-Scale Cortical Networks Based on Multiple Morphological Features in Amnestic Mild Cognitive Impairment. Neural Plasticity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113079
Modern Language Association (MLA)
Li, Qiongling…[et al.]. Topological Properties of Large-Scale Cortical Networks Based on Multiple Morphological Features in Amnestic Mild Cognitive Impairment. Neural Plasticity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1113079
American Medical Association (AMA)
Li, Qiongling& Li, Xinwei& Wang, Xuetong& Li, Yuxia& Li, Kuncheng& Yu, Yang…[et al.]. Topological Properties of Large-Scale Cortical Networks Based on Multiple Morphological Features in Amnestic Mild Cognitive Impairment. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113079
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113079