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Altered Local Spontaneous Brain Activity in Juvenile Myoclonic Epilepsy: A Preliminary Resting-State fMRI Study
Joint Authors
Yao, Dezhong
Dong, Li
Luo, Cheng
Li, Hong
Jiang, Sisi
Hou, Changyue
Wang, Pu
Zhong, Chengqing
Lai, Yongxiu
Xia, Yang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
The purpose of this study was to evaluate the regional synchronization of brain in patients with juvenile myoclonic epilepsy (JME).
Methods.
Resting-state fMRI data were acquired from twenty-one patients with JME and twenty-two healthy subjects.
Regional homogeneity (ReHo) was used to analyze the spontaneous activity in whole brain.
Two-sample t -test was performed to detect the ReHo difference between two groups.
Correlations between the ReHo values and features of seizures were calculated further.
Key Findings.
Compared with healthy controls, patients showed significantly increased ReHo in bilateral thalami and motor-related cortex regions and a substantial reduction of ReHo in cerebellum and occipitoparietal lobe.
In addition, greater ReHo value in the left paracentral lobule was linked to the older age of onset in patients.
Significance.
These findings implicated the abnormality of thalamomotor cortical network in JME which were associated with the genesis and propagation of epileptiform activity.
Moreover, our study supported that the local brain spontaneous activity is a potential tool to investigate the epileptic activity and provided important insights into understanding the pathophysiological mechanisms of JME.
American Psychological Association (APA)
Jiang, Sisi& Luo, Cheng& Li, Hong& Hou, Changyue& Wang, Pu& Dong, Li…[et al.]. 2015. Altered Local Spontaneous Brain Activity in Juvenile Myoclonic Epilepsy: A Preliminary Resting-State fMRI Study. Neural Plasticity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113096
Modern Language Association (MLA)
Jiang, Sisi…[et al.]. Altered Local Spontaneous Brain Activity in Juvenile Myoclonic Epilepsy: A Preliminary Resting-State fMRI Study. Neural Plasticity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1113096
American Medical Association (AMA)
Jiang, Sisi& Luo, Cheng& Li, Hong& Hou, Changyue& Wang, Pu& Dong, Li…[et al.]. Altered Local Spontaneous Brain Activity in Juvenile Myoclonic Epilepsy: A Preliminary Resting-State fMRI Study. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113096
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113096