The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease
Joint Authors
Cardinale, Alessio
Merlo, Daniela
Narciso, Laura
Parlanti, Eleonora
Racaniello, Mauro
Simonelli, Valeria
Dogliotti, Eugenia
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
There is a growing body of evidence indicating that the mechanisms that control genome stability are of key importance in the development and function of the nervous system.
The major threat for neurons is oxidative DNA damage, which is repaired by the base excision repair (BER) pathway.
Functional mutations of enzymes that are involved in the processing of single-strand breaks (SSB) that are generated during BER have been causally associated with syndromes that present important neurological alterations and cognitive decline.
In this review, the plasticity of BER during neurogenesis and the importance of an efficient BER for correct brain function will be specifically addressed paying particular attention to the brain region and neuron-selectivity in SSB repair-associated neurological syndromes and age-related neurodegenerative diseases.
American Psychological Association (APA)
Narciso, Laura& Parlanti, Eleonora& Racaniello, Mauro& Simonelli, Valeria& Cardinale, Alessio& Merlo, Daniela…[et al.]. 2016. The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease. Neural Plasticity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113101
Modern Language Association (MLA)
Narciso, Laura…[et al.]. The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease. Neural Plasticity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1113101
American Medical Association (AMA)
Narciso, Laura& Parlanti, Eleonora& Racaniello, Mauro& Simonelli, Valeria& Cardinale, Alessio& Merlo, Daniela…[et al.]. The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113101
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113101