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The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity
Joint Authors
Kwok, Jessica C.
Fawcett, J. W.
Vo, T. T.
Verhaagen, J.
de Winter, Fred
Carulli, Daniela
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-14
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
During postnatal development, closure of critical periods coincides with the appearance of extracellular matrix structures, called perineuronal nets (PNN), around various neuronal populations throughout the brain.
The absence or presence of PNN strongly correlates with neuronal plasticity.
It is not clear how PNN regulate plasticity.
The repulsive axon guidance proteins Semaphorin (Sema) 3A and Sema3B are also prominently expressed in the postnatal and adult brain.
In the neocortex, Sema3A accumulates in the PNN that form around parvalbumin positive inhibitory interneurons during the closure of critical periods.
Sema3A interacts with high-affinity with chondroitin sulfate E, a component of PNN.
The localization of Sema3A in PNN and its inhibitory effects on developing neurites are intriguing features and may clarify how PNN mediate structural neural plasticity.
In the cerebellum, enhanced neuronal plasticity as a result of an enriched environment correlates with reduced Sema3A expression in PNN.
Here, we first review the distribution of Sema3A and Sema3B expression in the rat brain and the biochemical interaction of Sema3A with PNN.
Subsequently, we review what is known so far about functional correlates of changes in Sema3A expression in PNN.
Finally, we propose a model of how Semaphorins in the PNN may influence local connectivity.
American Psychological Association (APA)
de Winter, Fred& Kwok, Jessica C.& Fawcett, J. W.& Vo, T. T.& Carulli, Daniela& Verhaagen, J.. 2016. The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity. Neural Plasticity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113103
Modern Language Association (MLA)
de Winter, Fred…[et al.]. The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity. Neural Plasticity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1113103
American Medical Association (AMA)
de Winter, Fred& Kwok, Jessica C.& Fawcett, J. W.& Vo, T. T.& Carulli, Daniela& Verhaagen, J.. The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113103