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Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells
Joint Authors
Linta, Leonhard
Grabrucker, Andreas M.
Pfaender, Stefanie
Föhr, Karl
Lutz, Anne-Kathrin
Putz, Stefan
Achberger, Kevin
Liebau, Stefan
Boeckers, Tobias M.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-09
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Disturbances in neuronal differentiation and function are an underlying factor of many brain disorders.
Zinc homeostasis and signaling are important mediators for a normal brain development and function, given that zinc deficiency was shown to result in cognitive and emotional deficits in animal models that might be associated with neurodevelopmental disorders.
One underlying mechanism of the observed detrimental effects of zinc deficiency on the brain might be impaired proliferation and differentiation of stem cells participating in neurogenesis.
Thus, to examine the molecular mechanisms regulating zinc metabolism and signaling in differentiating neurons, using a protocol for motor neuron differentiation, we characterized the expression of zinc homeostasis genes during neurogenesis using human induced pluripotent stem cells (hiPSCs) and evaluated the influence of altered zinc levels on the expression of zinc homeostasis genes, cell survival, cell fate, and neuronal function.
Our results show that zinc transporters are highly regulated genes during neuronal differentiation and that low zinc levels are associated with decreased cell survival, altered neuronal differentiation, and, in particular, synaptic function.
We conclude that zinc deficiency in a critical time window during brain development might influence brain function by modulating neuronal differentiation.
American Psychological Association (APA)
Pfaender, Stefanie& Föhr, Karl& Lutz, Anne-Kathrin& Putz, Stefan& Achberger, Kevin& Linta, Leonhard…[et al.]. 2016. Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells. Neural Plasticity،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113108
Modern Language Association (MLA)
Pfaender, Stefanie…[et al.]. Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells. Neural Plasticity No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1113108
American Medical Association (AMA)
Pfaender, Stefanie& Föhr, Karl& Lutz, Anne-Kathrin& Putz, Stefan& Achberger, Kevin& Linta, Leonhard…[et al.]. Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113108
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113108