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Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model
Joint Authors
Jung, Hyun Ho
Shin, Jaewoo
Kim, Jinhyung
Ahn, Seung-Hee
Lee, Sung Eun
Koh, Chin Su
Cho, Jae Sung
Kong, Chanho
Shin, Hyung-Cheul
Chang, Jin Woo
Kim, Sung June
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
It is well known that the insular cortex is involved in the processing of painful input.
The aim of this study was to evaluate the pain modulation role of the insular cortex during motor cortex stimulation (MCS).
After inducing neuropathic pain (NP) rat models by the spared nerve injury method, we made a lesion on the rostral agranular insular cortex (RAIC) unilaterally and compared behaviorally determined pain threshold and latency in 2 groups: Group A (NP + MCS; n = 7 ) and Group B (NP + RAIC lesion + MCS; n = 7 ).
Also, we simultaneously recorded neuronal activity (NP; n = 9 ) in the thalamus of the ventral posterolateral nucleus and RAIC to evaluate electrophysiological changes from MCS.
The pain threshold and tolerance latency increased in Group A with “MCS on” and in Group B with or without “MCS on.” Moreover, its increase in Group B with “MCS on” was more than that of Group B without MCS or of Group A, suggesting that MCS and RAIC lesioning are involved in pain modulation.
Compared with the “MCS off” condition, the “MCS on” induced significant threshold changes in an electrophysiological study.
Our data suggest that the RAIC has its own pain modulation effect, which is influenced by MCS.
American Psychological Association (APA)
Jung, Hyun Ho& Shin, Jaewoo& Kim, Jinhyung& Ahn, Seung-Hee& Lee, Sung Eun& Koh, Chin Su…[et al.]. 2016. Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model. Neural Plasticity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113111
Modern Language Association (MLA)
Jung, Hyun Ho…[et al.]. Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model. Neural Plasticity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113111
American Medical Association (AMA)
Jung, Hyun Ho& Shin, Jaewoo& Kim, Jinhyung& Ahn, Seung-Hee& Lee, Sung Eun& Koh, Chin Su…[et al.]. Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113111