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Mechanisms Underlying Adaptation of Respiratory Network Activity to Modulatory Stimuli in the Mouse Embryo
Joint Authors
Chevalier, Marc
De Sa, Rafaël
Cardoit, Laura
Thoby-Brisson, Muriel
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Breathing is a rhythmic behavior that requires organized contractions of respiratory effector muscles.
This behavior must adapt to constantly changing conditions in order to ensure homeostasis, proper body oxygenation, and CO2/pH regulation.
Respiratory rhythmogenesis is controlled by neural networks located in the brainstem.
One area considered to be essential for generating the inspiratory phase of the respiratory rhythm is the preBötzinger complex (preBötC).
Rhythmogenesis emerges from this network through the interplay between the activation of intrinsic cellular properties (pacemaker properties) and intercellular synaptic connections.
Respiratory activity continuously changes under the impact of numerous modulatory substances depending on organismal needs and environmental conditions.
The preBötC network has been shown to become active during the last third of gestation.
But only little is known regarding the modulation of inspiratory rhythmicity at embryonic stages and even less on a possible role of pacemaker neurons in this functional flexibility during the prenatal period.
By combining electrophysiology and calcium imaging performed on embryonic brainstem slice preparations, we provide evidence showing that embryonic inspiratory pacemaker neurons are already intrinsically sensitive to neuromodulation and external conditions (i.e., temperature) affecting respiratory network activity, suggesting a potential role of pacemaker neurons in mediating rhythm adaptation to modulatory stimuli in the embryo.
American Psychological Association (APA)
Chevalier, Marc& De Sa, Rafaël& Cardoit, Laura& Thoby-Brisson, Muriel. 2016. Mechanisms Underlying Adaptation of Respiratory Network Activity to Modulatory Stimuli in the Mouse Embryo. Neural Plasticity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113113
Modern Language Association (MLA)
Chevalier, Marc…[et al.]. Mechanisms Underlying Adaptation of Respiratory Network Activity to Modulatory Stimuli in the Mouse Embryo. Neural Plasticity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113113
American Medical Association (AMA)
Chevalier, Marc& De Sa, Rafaël& Cardoit, Laura& Thoby-Brisson, Muriel. Mechanisms Underlying Adaptation of Respiratory Network Activity to Modulatory Stimuli in the Mouse Embryo. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113113
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113113