Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk
Joint Authors
Zhang, Jianye
Wang, Junjie
Tang, Yingying
Zhang, Tianhong
Cui, Huiru
Xu, Lihua
Zeng, Botao
Li, Yu
Li, Gaiying
Li, Chunbo
Liu, Hui
Lu, Zheng
Wang, Jijun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Altered γ-aminobutyric acid (GABA), glutamate (Glu) levels, and an imbalance between GABAergic and glutamatergic neurotransmissions have been involved in the pathophysiology of schizophrenia.
However, it remains unclear how these abnormalities impact the onset and course of psychosis.
In the present study, 21 drug-naïve subjects at ultrahigh risk for psychosis (UHR), 16 drug-naïve patients with first-episode schizophrenia (FES), and 23 healthy controls (HC) were enrolled.
In vivo GABA and glutamate+glutamine (Glx) levels in the medial prefrontal cortex were measured using proton magnetic resonance spectroscopy.
Medial prefrontal GABA and Glx levels in FES patients were significantly lower than those in HC and UHR, respectively.
GABA and Glx levels in UHR were comparable with those in HC.
In each group, there was a positive correlation between GABA and Glx levels.
Reduced medial prefrontal GABA and Glx levels thus may play an important role in the early stages of schizophrenia.
American Psychological Association (APA)
Wang, Junjie& Tang, Yingying& Zhang, Tianhong& Cui, Huiru& Xu, Lihua& Zeng, Botao…[et al.]. 2016. Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk. Neural Plasticity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113114
Modern Language Association (MLA)
Wang, Junjie…[et al.]. Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk. Neural Plasticity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113114
American Medical Association (AMA)
Wang, Junjie& Tang, Yingying& Zhang, Tianhong& Cui, Huiru& Xu, Lihua& Zeng, Botao…[et al.]. Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113114
