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Protective Effect of Edaravone on Glutamate-Induced Neurotoxicity in Spiral Ganglion Neurons
Joint Authors
Sun, Qian
Li, Jianfeng
Bai, Xiaohui
Zhang, Chi
Wang, Haibo
Chen, Aiping
Liu, Wenwen
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Glutamate is an important excitatory neurotransmitter in mammalian brains, but excessive amount of glutamate can cause “excitotoxicity” and lead to neuronal death.
As bipolar neurons, spiral ganglion neurons (SGNs) function as a “bridge” in transmitting auditory information from the ear to the brain and can be damaged by excessive glutamate which results in sensorineural hearing loss.
In this study, edaravone, a free radical scavenger, elicited both preventative and therapeutic effects on SGNs against glutamate-induced cell damage that was tested by MTT assay and trypan blue staining.
Ho.33342 and PI double staining revealed that apoptosis as well as necrosis took place during glutamate treatment, and apoptosis was the main type of cell death.
Oxidative stress played an important role in glutamate-induced cell damage but pretreatment with edaravone alleviated cell death.
Results of western blot demonstrated that mechanisms underlying the toxicity of glutamate and the protection of edaravone were related to the PI3K pathway and Bcl-2 protein family.
American Psychological Association (APA)
Bai, Xiaohui& Zhang, Chi& Chen, Aiping& Liu, Wenwen& Li, Jianfeng& Sun, Qian…[et al.]. 2016. Protective Effect of Edaravone on Glutamate-Induced Neurotoxicity in Spiral Ganglion Neurons. Neural Plasticity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113119
Modern Language Association (MLA)
Bai, Xiaohui…[et al.]. Protective Effect of Edaravone on Glutamate-Induced Neurotoxicity in Spiral Ganglion Neurons. Neural Plasticity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113119
American Medical Association (AMA)
Bai, Xiaohui& Zhang, Chi& Chen, Aiping& Liu, Wenwen& Li, Jianfeng& Sun, Qian…[et al.]. Protective Effect of Edaravone on Glutamate-Induced Neurotoxicity in Spiral Ganglion Neurons. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113119