The Neuroprotective Effect of the Association of Aquaporin-4Glutamate Transporter-1 against Alzheimer’s Disease
Joint Authors
Lan, Yu-Long
Zou, Shuang
Chen, Jian-Jiao
Zhao, Jie
Li, Shao
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is characterized by memory loss and cognitive dysfunction.
Aquaporin-4 (AQP4), which is primarily expressed in astrocytes, is the major water channel expressed in the central nervous system (CNS).
This protein plays an important role in water and ion homeostasis in the normal brain and in various brain pathological conditions.
Emerging evidence suggests that AQP4 deficiency impairs learning and memory and that this may be related to the expression of glutamate transporter-1 (GLT-1).
Moreover, the colocalization of AQP4 and GLT-1 has long been studied in brain tissue; however, far less is known about the potential influence that the AQP4/GLT-1 complex may have on AD.
Research on the functional interaction of AQP4 and GLT-1 has been demonstrated to be of great significance in the study of AD.
Here, we review the interaction of AQP4 and GLT-1 in astrocytes, which might play a pivotal role in the regulation of distinct cellular responses that involve neuroprotection against AD.
The association of AQP4 and GLT-1 could greatly supplement previous research regarding neuroprotection against AD.
American Psychological Association (APA)
Lan, Yu-Long& Zou, Shuang& Chen, Jian-Jiao& Zhao, Jie& Li, Shao. 2016. The Neuroprotective Effect of the Association of Aquaporin-4Glutamate Transporter-1 against Alzheimer’s Disease. Neural Plasticity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113151
Modern Language Association (MLA)
Lan, Yu-Long…[et al.]. The Neuroprotective Effect of the Association of Aquaporin-4Glutamate Transporter-1 against Alzheimer’s Disease. Neural Plasticity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113151
American Medical Association (AMA)
Lan, Yu-Long& Zou, Shuang& Chen, Jian-Jiao& Zhao, Jie& Li, Shao. The Neuroprotective Effect of the Association of Aquaporin-4Glutamate Transporter-1 against Alzheimer’s Disease. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113151