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Interhemispheric Plasticity following Intermittent Theta Burst Stimulation in Chronic Poststroke Aphasia
Joint Authors
Griffis, Joseph C.
Nenert, Rodolphe
Allendorfer, Jane B.
Szaflarski, Jerzy P.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-10
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The effects of noninvasive neurostimulation on brain structure and function in chronic poststroke aphasia are poorly understood.
We investigated the effects of intermittent theta burst stimulation (iTBS) applied to residual language-responsive cortex in chronic patients using functional and anatomical MRI data acquired before and after iTBS.
Lateralization index (LI) analyses, along with comparisons of inferior frontal gyrus (IFG) activation and connectivity during covert verb generation, were used to assess changes in cortical language function.
Voxel-based morphometry (VBM) was used to assess effects on regional grey matter (GM).
LI analyses revealed a leftward shift in IFG activity after treatment.
While left IFG activation increased, right IFG activation decreased.
Changes in right to left IFG connectivity during covert verb generation also decreased after iTBS.
Behavioral correlations revealed a negative relationship between changes in right IFG activation and improvements in fluency.
While anatomical analyses did not reveal statistically significant changes in grey matter volume, the fMRI results provide evidence for changes in right and left IFG function after iTBS.
The negative relationship between post-iTBS changes in right IFG activity during covert verb generation and improvements in fluency suggests that iTBS applied to residual left-hemispheric language areas may reduce contralateral responses related to language production and facilitate recruitment of residual language areas after stroke.
American Psychological Association (APA)
Griffis, Joseph C.& Nenert, Rodolphe& Allendorfer, Jane B.& Szaflarski, Jerzy P.. 2016. Interhemispheric Plasticity following Intermittent Theta Burst Stimulation in Chronic Poststroke Aphasia. Neural Plasticity،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113158
Modern Language Association (MLA)
Griffis, Joseph C.…[et al.]. Interhemispheric Plasticity following Intermittent Theta Burst Stimulation in Chronic Poststroke Aphasia. Neural Plasticity No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1113158
American Medical Association (AMA)
Griffis, Joseph C.& Nenert, Rodolphe& Allendorfer, Jane B.& Szaflarski, Jerzy P.. Interhemispheric Plasticity following Intermittent Theta Burst Stimulation in Chronic Poststroke Aphasia. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113158
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113158