Role of MicroRNA in Governing Synaptic Plasticity
Joint Authors
Ye, Yuqin
Xu, Hongyu
Su, Xinhong
He, Xiaosheng
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Although synaptic plasticity in neural circuits is orchestrated by an ocean of genes, molecules, and proteins, the underlying mechanisms remain poorly understood.
Recently, it is well acknowledged that miRNA exerts widespread regulation over the translation and degradation of target gene in nervous system.
Increasing evidence suggests that quite a few specific miRNAs play important roles in various respects of synaptic plasticity including synaptogenesis, synaptic morphology alteration, and synaptic function modification.
More importantly, the miRNA-mediated regulation of synaptic plasticity is not only responsible for synapse development and function but also involved in the pathophysiology of plasticity-related diseases.
A review is made here on the function of miRNAs in governing synaptic plasticity, emphasizing the emerging regulatory role of individual miRNAs in synaptic morphological and functional plasticity, as well as their implications in neurological disorders.
Understanding of the way in which miRNAs contribute to synaptic plasticity provides rational clues in establishing the novel therapeutic strategy for plasticity-related diseases.
American Psychological Association (APA)
Ye, Yuqin& Xu, Hongyu& Su, Xinhong& He, Xiaosheng. 2016. Role of MicroRNA in Governing Synaptic Plasticity. Neural Plasticity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113168
Modern Language Association (MLA)
Ye, Yuqin…[et al.]. Role of MicroRNA in Governing Synaptic Plasticity. Neural Plasticity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1113168
American Medical Association (AMA)
Ye, Yuqin& Xu, Hongyu& Su, Xinhong& He, Xiaosheng. Role of MicroRNA in Governing Synaptic Plasticity. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113168
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113168