The Involvement of Neuron-Specific Factors in Dendritic Spinogenesis: Molecular Regulation and Association with Neurological Disorders
Joint Authors
Hu, Hsiao-Tang
Shih, Pu-Yun
Shih, Yu-Tzu
Hsueh, Yi-Ping
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Dendritic spines are the location of excitatory synapses in the mammalian nervous system and are neuron-specific subcellular structures essential for neural circuitry and function.
Dendritic spine morphology is determined by the F-actin cytoskeleton.
F-actin remodeling must coordinate with different stages of dendritic spinogenesis, starting from dendritic filopodia formation to the filopodia-spines transition and dendritic spine maturation and maintenance.
Hundreds of genes, including F-actin cytoskeleton regulators, membrane proteins, adaptor proteins, and signaling molecules, are known to be involved in regulating synapse formation.
Many of these genes are not neuron-specific, but how they specifically control dendritic spine formation in neurons is an intriguing question.
Here, we summarize how ubiquitously expressed genes, including syndecan-2, NF1 (encoding neurofibromin protein), VCP, and CASK, and the neuron-specific gene CTTNBP2 coordinate with neurotransmission, transsynaptic signaling, and cytoskeleton rearrangement to control dendritic filopodia formation, filopodia-spines transition, and dendritic spine maturation and maintenance.
The aforementioned genes have been associated with neurological disorders, such as autism spectrum disorders (ASDs), mental retardation, learning difficulty, and frontotemporal dementia.
We also summarize the corresponding disorders in this report.
American Psychological Association (APA)
Hu, Hsiao-Tang& Shih, Pu-Yun& Shih, Yu-Tzu& Hsueh, Yi-Ping. 2015. The Involvement of Neuron-Specific Factors in Dendritic Spinogenesis: Molecular Regulation and Association with Neurological Disorders. Neural Plasticity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113179
Modern Language Association (MLA)
Hu, Hsiao-Tang…[et al.]. The Involvement of Neuron-Specific Factors in Dendritic Spinogenesis: Molecular Regulation and Association with Neurological Disorders. Neural Plasticity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113179
American Medical Association (AMA)
Hu, Hsiao-Tang& Shih, Pu-Yun& Shih, Yu-Tzu& Hsueh, Yi-Ping. The Involvement of Neuron-Specific Factors in Dendritic Spinogenesis: Molecular Regulation and Association with Neurological Disorders. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113179