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Neuron-Glia Interactions in Neural Plasticity: Contributions of Neural Extracellular Matrix and Perineuronal Nets
Joint Authors
Dzyubenko, Egor
Gottschling, Christine
Faissner, Andreas
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Synapses are specialized structures that mediate rapid and efficient signal transmission between neurons and are surrounded by glial cells.
Astrocytes develop an intimate association with synapses in the central nervous system (CNS) and contribute to the regulation of ion and neurotransmitter concentrations.
Together with neurons, they shape intercellular space to provide a stable milieu for neuronal activity.
Extracellular matrix (ECM) components are synthesized by both neurons and astrocytes and play an important role in the formation, maintenance, and function of synapses in the CNS.
The components of the ECM have been detected near glial processes, which abut onto the CNS synaptic unit, where they are part of the specialized macromolecular assemblies, termed perineuronal nets (PNNs).
PNNs have originally been discovered by Golgi and represent a molecular scaffold deposited in the interface between the astrocyte and subsets of neurons in the vicinity of the synapse.
Recent reports strongly suggest that PNNs are tightly involved in the regulation of synaptic plasticity.
Moreover, several studies have implicated PNNs and the neural ECM in neuropsychiatric diseases.
Here, we highlight current concepts relating to neural ECM and PNNs and describe an in vitro approach that allows for the investigation of ECM functions for synaptogenesis.
American Psychological Association (APA)
Dzyubenko, Egor& Gottschling, Christine& Faissner, Andreas. 2016. Neuron-Glia Interactions in Neural Plasticity: Contributions of Neural Extracellular Matrix and Perineuronal Nets. Neural Plasticity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113180
Modern Language Association (MLA)
Dzyubenko, Egor…[et al.]. Neuron-Glia Interactions in Neural Plasticity: Contributions of Neural Extracellular Matrix and Perineuronal Nets. Neural Plasticity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1113180
American Medical Association (AMA)
Dzyubenko, Egor& Gottschling, Christine& Faissner, Andreas. Neuron-Glia Interactions in Neural Plasticity: Contributions of Neural Extracellular Matrix and Perineuronal Nets. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113180
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113180