Dynamic Alterations of miR-34c Expression in the Hypothalamus of Male Rats after Early Adolescent Traumatic Stress
Joint Authors
Li, Chuting
Liu, Yuan
Liu, Dexiang
Jiang, Hong
Pan, Fang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Several types of microRNA (miRNA) overexpression in the brain are associated with stress.
One of the targets of miR-34c is the stress-related corticotrophin releasing factor receptor 1 mRNA (CRFR1 mRNA).
Here we will probe into the short-term effect and long-term effect of early adolescent traumatic stress on the expression of miR-34c and CRFR1 mRNA.
Traumatic stress was established by electric foot shock for six consecutive days using 28-day rats.
The anxiety-like behaviors, memory damage, CRFR1 protein, CRFR1 mRNA, and miR-34c expression were detected in our study.
The results of our study proved that exposure to acute traumatic stress in early adolescent can cause permanent changes in neural network, resulting in dysregulation of CRFR1 expression and CRFR1 mRNA and miR-34c expression in hypothalamus, anxiety-like behavior, and memory impairment, suggesting that the miR-34c expression in hypothalamus may be an important factor involved in susceptibility to PTSD.
American Psychological Association (APA)
Li, Chuting& Liu, Yuan& Liu, Dexiang& Jiang, Hong& Pan, Fang. 2016. Dynamic Alterations of miR-34c Expression in the Hypothalamus of Male Rats after Early Adolescent Traumatic Stress. Neural Plasticity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113183
Modern Language Association (MLA)
Li, Chuting…[et al.]. Dynamic Alterations of miR-34c Expression in the Hypothalamus of Male Rats after Early Adolescent Traumatic Stress. Neural Plasticity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113183
American Medical Association (AMA)
Li, Chuting& Liu, Yuan& Liu, Dexiang& Jiang, Hong& Pan, Fang. Dynamic Alterations of miR-34c Expression in the Hypothalamus of Male Rats after Early Adolescent Traumatic Stress. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113183