Coordinated Plasticity between Barrel Cortical Glutamatergic and GABAergic Neurons during Associative Memory
Joint Authors
Yan, Fenxia
Gao, Zilong
Chen, Pin
Huang, Li
Wang, Dangui
Chen, Na
Wu, Ruixiang
Feng, Jing
Cui, Shan
Lu, Wei
Wang, Jin-Hui
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-14
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Neural plasticity is associated with memory formation.
The coordinated refinement and interaction between cortical glutamatergic and GABAergic neurons remain elusive in associative memory, which we examine in a mouse model of associative learning.
In the mice that show odorant-induced whisker motion after pairing whisker and odor stimulations, the barrel cortical glutamatergic and GABAergic neurons are recruited to encode the newly learnt odor signal alongside the innate whisker signal.
These glutamatergic neurons are functionally upregulated, and GABAergic neurons are refined in a homeostatic manner.
The mutual innervations between these glutamatergic and GABAergic neurons are upregulated.
The analyses by high throughput sequencing show that certain microRNAs related to regulating synapses and neurons are involved in this cross-modal reflex.
Thus, the coactivation of the sensory cortices through epigenetic processes recruits their glutamatergic and GABAergic neurons to be the associative memory cells as well as drive their coordinated refinements toward the optimal state for the storage of the associated signals.
American Psychological Association (APA)
Yan, Fenxia& Gao, Zilong& Chen, Pin& Huang, Li& Wang, Dangui& Chen, Na…[et al.]. 2016. Coordinated Plasticity between Barrel Cortical Glutamatergic and GABAergic Neurons during Associative Memory. Neural Plasticity،Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1113191
Modern Language Association (MLA)
Yan, Fenxia…[et al.]. Coordinated Plasticity between Barrel Cortical Glutamatergic and GABAergic Neurons during Associative Memory. Neural Plasticity No. 2016 (2016), pp.1-20.
https://search.emarefa.net/detail/BIM-1113191
American Medical Association (AMA)
Yan, Fenxia& Gao, Zilong& Chen, Pin& Huang, Li& Wang, Dangui& Chen, Na…[et al.]. Coordinated Plasticity between Barrel Cortical Glutamatergic and GABAergic Neurons during Associative Memory. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1113191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113191