Genetic Regulation of Maternal Oxytocin Response and Its Influences on Maternal Behavior
Joint Authors
Barnett, Bryanne
Mehta, Divya
Kohlhoff, Jane
Mendoza Diaz, Antonio
Silove, Derrick
Dadds, Mark R.
Eapen, Valsamma
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We interrogated the genetic modulation of maternal oxytocin response and its association with maternal behavior using genetic risk scores within the oxytocin receptor (OXTR) gene.
We identified a novel SNP, rs968389, to be significantly associated with maternal oxytocin response after a challenging mother-infant interaction task (Still Face Paradigm) and maternal separation anxiety from the infant.
Performing a multiallelic analysis across OXTR by calculating a cumulative genetic risk score revealed a significant gene-by-environment (G×E) interaction, with OXTR genetic risk score interacting with adult separation anxiety to modulate levels of maternal sensitivity.
Mothers with higher OXTR genetic risk score and adult separation anxiety showed significantly reduced levels of maternal sensitivity during free play with the infant.
The same G×E interaction was also observed for the extended OXTR cumulative genetic risk score that included rs968389.
Moreover, the extended cumulative OXTR genetic risk score itself was found to be significantly associated with maternal separation anxiety as it specifically relates to the infant.
Our results suggest a complex montage of individual and synergistic genetic mediators of maternal behavior.
These findings add to specific knowledge about genetic regulation of maternal oxytocin response in relation to maternal adjustment and infant bonding through the first few months of life.
American Psychological Association (APA)
Mehta, Divya& Eapen, Valsamma& Kohlhoff, Jane& Mendoza Diaz, Antonio& Barnett, Bryanne& Silove, Derrick…[et al.]. 2016. Genetic Regulation of Maternal Oxytocin Response and Its Influences on Maternal Behavior. Neural Plasticity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113193
Modern Language Association (MLA)
Mehta, Divya…[et al.]. Genetic Regulation of Maternal Oxytocin Response and Its Influences on Maternal Behavior. Neural Plasticity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1113193
American Medical Association (AMA)
Mehta, Divya& Eapen, Valsamma& Kohlhoff, Jane& Mendoza Diaz, Antonio& Barnett, Bryanne& Silove, Derrick…[et al.]. Genetic Regulation of Maternal Oxytocin Response and Its Influences on Maternal Behavior. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113193
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113193