Regeneration of Zebrafish CNS: Adult Neurogenesis
Joint Authors
Ghosh, Sukla
Hui, Subhra Prakash
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-13
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Regeneration in the animal kingdom is one of the most fascinating problems that have allowed scientists to address many issues of fundamental importance in basic biology.
However, we came to know that the regenerative capability may vary across different species.
Among vertebrates, fish and amphibians are capable of regenerating a variety of complex organs through epimorphosis.
Zebrafish is an excellent animal model, which can repair several organs like damaged retina, severed spinal cord, injured brain and heart, and amputated fins.
The focus of the present paper is on spinal cord regeneration in adult zebrafish.
We intend to discuss our current understanding of the cellular and molecular mechanism(s) that allows formation of proliferating progenitors and controls neurogenesis, which involve changes in epigenetic and transcription programs.
Unlike mammals, zebrafish retains radial glia, a nonneuronal cell type in their adult central nervous system.
Injury induced proliferation involves radial glia which proliferate, transcribe embryonic genes, and can give rise to new neurons.
Recent technological development of exquisite molecular tools in zebrafish, such as cell ablation, lineage analysis, and novel and substantial microarray, together with advancement in stem cell biology, allowed us to investigate how progenitor cells contribute to the generation of appropriate structures and various underlying mechanisms like reprogramming.
American Psychological Association (APA)
Ghosh, Sukla& Hui, Subhra Prakash. 2016. Regeneration of Zebrafish CNS: Adult Neurogenesis. Neural Plasticity،Vol. 2016, no. 2016, pp.1-21.
https://search.emarefa.net/detail/BIM-1113197
Modern Language Association (MLA)
Ghosh, Sukla& Hui, Subhra Prakash. Regeneration of Zebrafish CNS: Adult Neurogenesis. Neural Plasticity No. 2016 (2016), pp.1-21.
https://search.emarefa.net/detail/BIM-1113197
American Medical Association (AMA)
Ghosh, Sukla& Hui, Subhra Prakash. Regeneration of Zebrafish CNS: Adult Neurogenesis. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-21.
https://search.emarefa.net/detail/BIM-1113197
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113197