Neuroprotective Transcription Factors in Animal Models of Parkinson Disease
Joint Authors
Blaudin de Thé, François-Xavier
Rekaik, Hocine
Prochiantz, Alain
Fuchs, Julia
Joshi, Rajiv L.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
A number of transcription factors, including En1/2, Foxa1/2, Lmx1a/b, Nurr1, Otx2, and Pitx3, with key roles in midbrain dopaminergic (mDA) neuron development, also regulate adult mDA neuron survival and physiology.
Mouse models with targeted disruption of some of these genes display several features reminiscent of Parkinson disease (PD), in particular the selective and progressive loss of mDA neurons in the substantia nigra pars compacta (SNpc).
The characterization of these animal models has provided valuable insights into various mechanisms of PD pathogenesis.
Therefore, the dissection of the mechanisms and survival signalling pathways engaged by these transcription factors to protect mDA neuron from degeneration can suggest novel therapeutic strategies.
The work on En1/2-mediated neuroprotection also highlights the potential of protein transduction technology for neuroprotective approaches in PD.
American Psychological Association (APA)
Blaudin de Thé, François-Xavier& Rekaik, Hocine& Prochiantz, Alain& Fuchs, Julia& Joshi, Rajiv L.. 2015. Neuroprotective Transcription Factors in Animal Models of Parkinson Disease. Neural Plasticity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113208
Modern Language Association (MLA)
Blaudin de Thé, François-Xavier…[et al.]. Neuroprotective Transcription Factors in Animal Models of Parkinson Disease. Neural Plasticity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113208
American Medical Association (AMA)
Blaudin de Thé, François-Xavier& Rekaik, Hocine& Prochiantz, Alain& Fuchs, Julia& Joshi, Rajiv L.. Neuroprotective Transcription Factors in Animal Models of Parkinson Disease. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113208
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113208